Cell Senescence Entries for TNFSF13

Cell Types
Colon cancer
Cell Lines
SW480
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Ding et al. (2010) Reduced APRIL expression induces cellular senescence via a HSPG-dependent pathway. Pathol Oncol Res 15(4)693-701 (PubMed)

TNFSF13 Gene Information

HGNC symbol
TNFSF13 
Aliases
APRIL; CD256 
Common name
TNF superfamily member 13 
Entrez Id
8741
Description
The protein encoded by this gene is a member of the tumor necrosis factor (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vitro experiments suggested that this protein may be able to induce apoptosis through its interaction with other TNF receptor family proteins such as TNFRSF6/FAS and TNFRSF14/HVEM. Alternative splicing results in multiple transcript variants. Some transcripts that skip the last exon of the upstream gene (TNFSF12) and continue into the second exon of this gene have been identified; such read-through transcripts are contained in GeneID 407977, TNFSF12-TNFSF13. [provided by RefSeq, Oct 2010].

TNFSF13 Ontologies

Gene Ontology
Process: GO:6955; immune response
GO:7166; cell surface receptor signaling pathway
GO:2376; immune system process
GO:7165; signal transduction
GO:8284; positive regulation of cell population proliferation
GO:48298; positive regulation of isotype switching to IgA isotypes
Cellular component: GO:16020; membrane
GO:5615; extracellular space
GO:16021; integral component of membrane
GO:5737; cytoplasm
GO:5576; extracellular region
GO:5654; nucleoplasm
GO:5829; cytosol
GO:70062; extracellular exosome
Function: GO:5125; cytokine activity
GO:5164; tumor necrosis factor receptor binding
GO:5102; signaling receptor binding
GO:5515; protein binding
GO:48018; receptor ligand activity
Hide GO terms

Homologs of TNFSF13 in Model Organisms

Danio rerio
tnfsf13
Mus musculus
Tnfsf13
Rattus norvegicus
Tnfsf13

External links

OMIM
604472
Ensembl
ENSG00000161955
Entrez Gene
8741
UniGene
54673
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TNFSF13
GeneCards
TNFSF13