Cell Senescence Entries for TNFSF15

Cell Types
Endothelial progenitor
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Replicative
Senescence Effect
Induces
Primary Reference
Mück et al. (2010) Two functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain shedding. J Gerontol A Biol Sci Med Sci 65(11)1165-80 (PubMed)

TNFSF15 Gene Information

HGNC symbol
TNFSF15 
Aliases
MGC129934; MGC129935; TL1; TL1A; VEGI; VEGI192A 
Common name
TNF superfamily member 15 
Entrez Id
9966
Description
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein is abundantly expressed in endothelial cells, but is not expressed in either B or T cells. The expression of this protein is inducible by TNF and IL-1 alpha. This cytokine is a ligand for receptor TNFRSF25 and decoy receptor TNFRSF21/DR6. It can activate NF-kappaB and MAP kinases, and acts as an autocrine factor to induce apoptosis in endothelial cells. This cytokine is also found to inhibit endothelial cell proliferation, and thus may function as an angiogenesis inhibitor. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011].

TNFSF15 Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:6955; immune response
GO:6915; apoptotic process
GO:7166; cell surface receptor signaling pathway
GO:6919; activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:7250; activation of NF-kappaB-inducing kinase activity
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5576; extracellular region
GO:5615; extracellular space
GO:5886; plasma membrane
GO:5887; integral component of plasma membrane
Function: GO:5515; protein binding
GO:5125; cytokine activity
GO:5164; tumor necrosis factor receptor binding
GO:5102; signaling receptor binding
Hide GO terms

Homologs of TNFSF15 in Model Organisms

Mus musculus
Tnfsf15
Rattus norvegicus
Tnfsf15

External links

OMIM
604052
Ensembl
ENSG00000181634
Entrez Gene
9966
UniGene
23349
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TNFSF15
GeneCards
TNFSF15