The TP53 gene and its putative association with human ageing

Cell Types

Bladder cancer

Cell Lines

EJ

Cancer Cell?

Yes

Method

Overexpression

Type of senescence

Oncogene-induced, Replicative, Stress-induced

Senescence Effect

Induces

Primary Reference

Sugrue et al. (1997) Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53. Proc Natl Acad Sci U S A 94(18)9648-53 (PubMed)

HGNC symbol

TP53

Aliases

LFS1; p53

Common name

tumor protein p53

Entrez Id

7157

Description

This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016].

Gene Ontology

Process:

GO:7049; cell cycle
GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:12501; programmed cell death
GO:45893; positive regulation of transcription, DNA-templated
GO:48511; rhythmic process
GO:51262; protein tetramerization
GO:10628; positive regulation of gene expression
GO:45892; negative regulation of transcription, DNA-templated
GO:6974; cellular response to DNA damage stimulus
GO:45944; positive regulation of transcription by RNA polymerase II
GO:43065; positive regulation of apoptotic process
GO:6289; nucleotide-excision repair
GO:6357; regulation of transcription by RNA polymerase II
GO:30308; negative regulation of cell growth
GO:43066; negative regulation of apoptotic process
GO:122; negative regulation of transcription by RNA polymerase II
GO:48512; circadian behavior
GO:50731; positive regulation of peptidyl-tyrosine phosphorylation
GO:8104; protein localization
GO:42981; regulation of apoptotic process
GO:71466; cellular response to xenobiotic stimulus
GO:65003; protein-containing complex assembly
GO:90200; positive regulation of release of cytochrome c from mitochondria
GO:2001244; positive regulation of intrinsic apoptotic signaling pathway
GO:90399; replicative senescence
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:33209; tumor necrosis factor-mediated signaling pathway
GO:8285; negative regulation of cell population proliferation
GO:9299; mRNA transcription
GO:7569; cell aging
GO:71456; cellular response to hypoxia
GO:42771; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:43153; entrainment of circadian clock by photoperiod
GO:42149; cellular response to glucose starvation
GO:72332; intrinsic apoptotic signaling pathway by p53 class mediator
GO:1990440; positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress
GO:30330; DNA damage response, signal transduction by p53 class mediator
GO:46677; response to antibiotic
GO:97252; oligodendrocyte apoptotic process
GO:60218; hematopoietic stem cell differentiation
GO:2244; hematopoietic progenitor cell differentiation
GO:1903800; positive regulation of production of miRNAs involved in gene silencing by miRNA
GO:2000379; positive regulation of reactive oxygen species metabolic process
GO:48147; negative regulation of fibroblast proliferation
GO:51726; regulation of cell cycle
GO:7265; Ras protein signal transduction
GO:71480; cellular response to gamma radiation
GO:1902749; regulation of cell cycle G2/M phase transition
GO:6983; ER overload response
GO:6914; autophagy
GO:6977; DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:6978; DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:8340; determination of adult lifespan
GO:10332; response to gamma radiation
GO:16032; viral process
GO:31497; chromatin assembly
GO:31571; mitotic G1 DNA damage checkpoint signaling
GO:34644; cellular response to UV
GO:36003; positive regulation of transcription from RNA polymerase II promoter in response to stress
GO:45899; positive regulation of RNA polymerase II transcription preinitiation complex assembly
GO:48539; bone marrow development
GO:51097; negative regulation of helicase activity
GO:51974; negative regulation of telomerase activity
GO:70245; positive regulation of thymocyte apoptotic process
GO:71479; cellular response to ionizing radiation
GO:72331; signal transduction by p53 class mediator
GO:72717; cellular response to actinomycin D
GO:90403; oxidative stress-induced premature senescence
GO:97193; intrinsic apoptotic signaling pathway
GO:1900119; positive regulation of execution phase of apoptosis
GO:1903451; negative regulation of G1 to G0 transition
GO:1905856; negative regulation of pentose-phosphate shunt
GO:1990248; regulation of transcription from RNA polymerase II promoter in response to DNA damage
GO:34613; cellular protein localization
GO:1701; in utero embryonic development
GO:1756; somitogenesis
GO:1836; release of cytochrome c from mitochondria
GO:2309; T cell proliferation involved in immune response
GO:2326; B cell lineage commitment
GO:2360; T cell lineage commitment
GO:2931; response to ischemia
GO:6302; double-strand break repair
GO:6606; protein import into nucleus
GO:6979; response to oxidative stress
GO:7179; transforming growth factor beta receptor signaling pathway
GO:7346; regulation of mitotic cell cycle
GO:7369; gastrulation
GO:7406; negative regulation of neuroblast proliferation
GO:7417; central nervous system development
GO:7507; heart development
GO:7623; circadian rhythm
GO:8156; negative regulation of DNA replication
GO:9303; rRNA transcription
GO:9410; response to xenobiotic stimulus
GO:9411; response to UV
GO:9651; response to salt stress
GO:9792; embryo development ending in birth or egg hatching
GO:10165; response to X-ray
GO:10629; negative regulation of gene expression
GO:10666; positive regulation of cardiac muscle cell apoptotic process
GO:21549; cerebellum development
GO:30512; negative regulation of transforming growth factor beta receptor signaling pathway
GO:31065; positive regulation of histone deacetylation
GO:33077; T cell differentiation in thymus
GO:34103; regulation of tissue remodeling
GO:35264; multicellular organism growth
GO:35794; positive regulation of mitochondrial membrane permeability
GO:42127; regulation of cell population proliferation
GO:43504; mitochondrial DNA repair
GO:43516; regulation of DNA damage response, signal transduction by p53 class mediator
GO:43523; regulation of neuron apoptotic process
GO:43525; positive regulation of neuron apoptotic process
GO:45861; negative regulation of proteolysis
GO:45930; negative regulation of mitotic cell cycle
GO:48568; embryonic organ development
GO:50821; protein stabilization
GO:51276; chromosome organization
GO:51402; neuron apoptotic process
GO:60333; interferon-gamma-mediated signaling pathway
GO:60411; cardiac septum morphogenesis
GO:61419; positive regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:62100; positive regulation of programmed necrotic cell death
GO:70059; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:70243; regulation of thymocyte apoptotic process
GO:70266; necroptotic process
GO:71494; cellular response to UV-C
GO:90343; positive regulation of cell aging
GO:1901525; negative regulation of mitophagy
GO:1902108; regulation of mitochondrial membrane permeability involved in apoptotic process
GO:1902253; regulation of intrinsic apoptotic signaling pathway by p53 class mediator
GO:1903799; negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1904024; negative regulation of glucose catabolic process to lactate via pyruvate
GO:1990144; intrinsic apoptotic signaling pathway in response to hypoxia
GO:2000269; regulation of fibroblast apoptotic process
GO:2000378; negative regulation of reactive oxygen species metabolic process
GO:2000772; regulation of cellular senescence

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:5783; endoplasmic reticulum
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5759; mitochondrial matrix
GO:16605; PML body
GO:5815; microtubule organizing center
GO:16020; membrane
GO:16021; integral component of membrane
GO:5739; mitochondrion
GO:5856; cytoskeleton
GO:5730; nucleolus
GO:5813; centrosome
GO:16363; nuclear matrix
GO:785; chromatin
GO:17053; transcription repressor complex
GO:32991; protein-containing complex
GO:16604; nuclear body
GO:5667; transcription regulator complex
GO:5657; replication fork
GO:35861; site of double-strand break

Function:

GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:976; transcription cis-regulatory region binding
GO:5515; protein binding
GO:8270; zinc ion binding
GO:31625; ubiquitin protein ligase binding
GO:42802; identical protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:19899; enzyme binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
GO:19901; protein kinase binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:5507; copper ion binding
GO:47485; protein N-terminus binding
GO:19903; protein phosphatase binding
GO:2020; protease binding
GO:46982; protein heterodimerization activity
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:51087; chaperone binding
GO:2039; p53 binding
GO:1990841; promoter-specific chromatin binding
GO:51721; protein phosphatase 2A binding
GO:987; cis-regulatory region sequence-specific DNA binding
GO:3730; mRNA 3'-UTR binding
GO:97718; disordered domain specific binding
GO:35035; histone acetyltransferase binding
GO:1046; core promoter sequence-specific DNA binding
GO:1094; TFIID-class transcription factor complex binding
GO:30971; receptor tyrosine kinase binding
GO:36310; ATP-dependent DNA/DNA annealing activity
GO:42826; histone deacetylase binding
GO:43621; protein self-association
GO:140296; general transcription initiation factor binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:35033; histone deacetylase regulator activity
GO:97371; MDM2/MDM4 family protein binding

Hide GO terms

Danio rerio

tp53

Mus musculus

Tp53

Rattus norvegicus

Tp53

GenAge model organism genes