Cell Senescence Entries for TP53BP1

Cell Types
Retinal pigment epithelial
Cell Lines
RPE-1
Cancer Cell?
No
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Fong et al. (2017) 53BP1 and USP28 mediate p53-dependent cell cycle arrest in response to centrosome loss and prolonged mitosis. Elife 5(2)117-26 (PubMed)

TP53BP1 Gene Information

HGNC symbol
TP53BP1 
Aliases
53BP1; p202; TDRD30 
Common name
tumor protein p53 binding protein 1 
Entrez Id
7158
Description
This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017].

TP53BP1 Ontologies

Gene Ontology
Process: GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:45893; positive regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:51260; protein homooligomerization
GO:2000042; negative regulation of double-strand break repair via homologous recombination
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:6303; double-strand break repair via nonhomologous end joining
GO:77; DNA damage checkpoint signaling
GO:45830; positive regulation of isotype switching
GO:71481; cellular response to X-ray
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:16604; nuclear body
GO:775; chromosome, centromeric region
GO:776; kinetochore
GO:35861; site of double-strand break
GO:5737; cytoplasm
GO:5657; replication fork
GO:1990391; DNA repair complex
GO:43229; intracellular organelle
Function: GO:3677; DNA binding
GO:5515; protein binding
GO:35064; methylated histone binding
GO:42393; histone binding
GO:61629; RNA polymerase II-specific DNA-binding transcription factor binding
GO:2039; p53 binding
GO:3712; transcription coregulator activity
GO:3684; damaged DNA binding
GO:42162; telomeric DNA binding
GO:43565; sequence-specific DNA binding
GO:61649; ubiquitin modification-dependent histone binding
Hide GO terms

Homologs of TP53BP1 in Model Organisms

Caenorhabditis elegans
hsr-9
Danio rerio
tp53bp1
Mus musculus
Tp53bp1
Rattus norvegicus
Tp53bp1

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Trp53bp1
GenAge human genes

External links

OMIM
605230
Ensembl
ENSG00000067369
Entrez Gene
7158
UniGene
584887
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TP53BP1
GeneCards
TP53BP1