Cell Senescence Entries for TP53BP2
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Wang et al. (2013) N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence. Proc Natl Acad Sci U S A 110(1)312-7 (PubMed)
TP53BP2 Gene Information
- HGNC symbol
- TP53BP2
- Aliases
- 53BP2; ASPP2; PPP1R13A
- Common name
- tumor protein p53 binding protein 2
- Entrez Id
- 7159
- Description
- This gene encodes a member of the ASPP (apoptosis-stimulating protein of p53) family of p53 interacting proteins. The protein contains four ankyrin repeats and an SH3 domain involved in protein-protein interactions. It is localized to the perinuclear region of the cytoplasm, and regulates apoptosis and cell growth through interactions with other regulatory molecules including members of the p53 family. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
TP53BP2 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:6915; apoptotic process
GO:45786; negative regulation of cell cycle
GO:7165; signal transduction
GO:72332; intrinsic apoptotic signaling pathway by p53 class mediator
GO:1900119; positive regulation of execution phase of apoptosis
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:5829; cytosol
GO:30054; cell junction
GO:48471; perinuclear region of cytoplasm
GO:5654; nucleoplasm
Hide GO termsFunction: GO:5515; protein binding
GO:17124; SH3 domain binding
GO:42802; identical protein binding
GO:2039; p53 binding
GO:51059; NF-kappaB binding
Homologs of TP53BP2 in Model Organisms
External links
- OMIM
- 602143
- Ensembl
- ENSG00000143514
- Entrez Gene
- 7159
- UniGene
- 523968
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- TP53BP2
- GeneCards
- TP53BP2