The TP63 gene and its putative association with human ageing

Cell Types

Foreskin fibroblast

Cell Lines

BJ

Cancer Cell?

No

Method

Knockout

Type of senescence

Oncogene-induced

Senescence Effect

Induces

Primary Reference

Guo et al. (2009) TAp63 induces senescence and suppresses tumorigenesis in vivo. Nat Cell Biol 11(12)1451-7 (PubMed)

HGNC symbol

TP63

Aliases

EEC3; KET; NBP; OFC8; p51; p53CP; p63; p73H; p73L; SHFM4; TP53CP; TP53L; TP73L

Common name

tumor protein p63

Entrez Id

8626

Description

This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016].

Gene Ontology

Process:

GO:6355; regulation of transcription, DNA-templated
GO:6915; apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:51262; protein tetramerization
GO:7219; Notch signaling pathway
GO:6357; regulation of transcription by RNA polymerase II
GO:32502; developmental process
GO:122; negative regulation of transcription by RNA polymerase II
GO:1501; skeletal system development
GO:1736; establishment of planar polarity
GO:1738; morphogenesis of a polarized epithelium
GO:1942; hair follicle development
GO:2064; epithelial cell development
GO:6338; chromatin remodeling
GO:7283; spermatogenesis
GO:7389; pattern specification process
GO:7499; ectoderm and mesoderm interaction
GO:7568; aging
GO:7569; cell aging
GO:8283; cell population proliferation
GO:8284; positive regulation of cell population proliferation
GO:8544; epidermis development
GO:9887; animal organ morphogenesis
GO:9913; epidermal cell differentiation
GO:9954; proximal/distal pattern formation
GO:10259; multicellular organism aging
GO:10481; epidermal cell division
GO:10482; regulation of epidermal cell division
GO:10838; positive regulation of keratinocyte proliferation
GO:30154; cell differentiation
GO:30216; keratinocyte differentiation
GO:30326; embryonic limb morphogenesis
GO:30850; prostate gland development
GO:30855; epithelial cell differentiation
GO:30859; polarized epithelial cell differentiation
GO:31069; hair follicle morphogenesis
GO:33147; negative regulation of intracellular estrogen receptor signaling pathway
GO:35115; embryonic forelimb morphogenesis
GO:35116; embryonic hindlimb morphogenesis
GO:36342; post-anal tail morphogenesis
GO:42475; odontogenesis of dentin-containing tooth
GO:42771; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:43281; regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:43589; skin morphogenesis
GO:45617; negative regulation of keratinocyte differentiation
GO:45747; positive regulation of Notch signaling pathway
GO:45944; positive regulation of transcription by RNA polymerase II
GO:48485; sympathetic nervous system development
GO:48646; anatomical structure formation involved in morphogenesis
GO:48807; female genitalia morphogenesis
GO:51402; neuron apoptotic process
GO:60197; cloacal septation
GO:60513; prostatic bud formation
GO:60529; squamous basal epithelial stem cell differentiation involved in prostate gland acinus development
GO:61436; establishment of skin barrier
GO:98773; skin epidermis development
GO:1904674; positive regulation of somatic stem cell population maintenance
GO:1904888; cranial skeletal system development
GO:2000381; negative regulation of mesoderm development
GO:2001235; positive regulation of apoptotic signaling pathway
GO:45669; positive regulation of osteoblast differentiation
GO:2000271; positive regulation of fibroblast apoptotic process
GO:6974; cellular response to DNA damage stimulus
GO:2000773; negative regulation of cellular senescence
GO:1902808; positive regulation of cell cycle G1/S phase transition
GO:7049; cell cycle

Cellular component:

GO:5634; nucleus
GO:5654; nucleoplasm
GO:5791; rough endoplasmic reticulum
GO:30425; dendrite
GO:32991; protein-containing complex
GO:43005; neuron projection
GO:785; chromatin
GO:5737; cytoplasm

Function:

GO:46872; metal ion binding
GO:3677; DNA binding
GO:42802; identical protein binding
GO:3700; DNA-binding transcription factor activity
GO:5515; protein binding
GO:976; transcription cis-regulatory region binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:3682; chromatin binding
GO:3684; damaged DNA binding
GO:3690; double-stranded DNA binding
GO:19904; protein domain specific binding
GO:43565; sequence-specific DNA binding
GO:2039; p53 binding
GO:97371; MDM2/MDM4 family protein binding
GO:50699; WW domain binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding

Hide GO terms

Danio rerio

tp63

Mus musculus

Tp63

Rattus norvegicus

Tp63

GenAge model organism genes