Cell Senescence Entries for TPP1

Cell Types
Lung fibroblast
Cell Lines
HFL1
Cancer Cell?
No
Method
Overexpression
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Ahmad et al. (2017) Shelterin Telomere Protection Protein 1 Reduction Causes Telomere Attrition and Cellular Senescence via Sirtuin 1 Deacetylase in Chronic Obstructive Pulmonary Disease. Am J Respir Cell Mol Biol 56(1)38-49 (PubMed)

TPP1 Gene Information

HGNC symbol
TPP1 
Aliases
CLN2; LPIC; SCAR7; TPP-1 
Common name
tripeptidyl peptidase 1 
Entrez Id
1200
Description
This gene encodes a member of the sedolisin family of serine proteases. The protease functions in the lysosome to cleave N-terminal tripeptides from substrates, and has weaker endopeptidase activity. It is synthesized as a catalytically-inactive enzyme which is activated and auto-proteolyzed upon acidification. Mutations in this gene result in late-infantile neuronal ceroid lipofuscinosis, which is associated with the failure to degrade specific neuropeptides and a subunit of ATP synthase in the lysosome. [provided by RefSeq, Jul 2008].

TPP1 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:7399; nervous system development
GO:7417; central nervous system development
GO:30855; epithelial cell differentiation
GO:6629; lipid metabolic process
GO:7040; lysosome organization
GO:30163; protein catabolic process
GO:43171; peptide catabolic process
GO:45453; bone resorption
GO:50885; neuromuscular process controlling balance
GO:70198; protein localization to chromosome, telomeric region
GO:1905146; lysosomal protein catabolic process
Cellular component: GO:5794; Golgi apparatus
GO:45121; membrane raft
GO:5764; lysosome
GO:42470; melanosome
GO:55037; recycling endosome
GO:70062; extracellular exosome
GO:43202; lysosomal lumen
Function: GO:5515; protein binding
GO:46872; metal ion binding
GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:4252; serine-type endopeptidase activity
GO:8236; serine-type peptidase activity
GO:8240; tripeptidyl-peptidase activity
GO:4175; endopeptidase activity
GO:35727; lysophosphatidic acid binding
GO:42277; peptide binding
GO:120146; sulfatide binding
Hide GO terms

Homologs of TPP1 in Model Organisms

Danio rerio
tpp1
Mus musculus
Tpp1
Rattus norvegicus
Tpp1

External links

OMIM
607998
Ensembl
ENSG00000166340
Entrez Gene
1200
UniGene
523454
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TPP1
GeneCards
TPP1