The TPR gene and its putative association with human ageing

Cell Senescence Entries for TPR

Cell Types: Cervical cancer, Melanoma, Osteosarcoma
Cell Lines: A375, HeLa, U2OS
Cancer Cell?: Yes
Method: Knockdown
Type of senescence: Unclear
Senescence Effect: Inhibits
Primary Reference: David-Watine et al. (2011) Silencing nuclear pore protein Tpr elicits a senescent-like phenotype in cancer cells. PLoS One 6(7)e22423 (PubMed)

TPR Gene Information

HGNC symbol: TPR
Aliases
Common name: translocated promoter region, nuclear basket protein
Entrez Id: 7175
Description: This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008].

TPR Ontologies

Gene Ontology

Process:

GO:51028; mRNA transport
GO:15031; protein transport
GO:7049; cell cycle
GO:51301; cell division
GO:122; negative regulation of transcription by RNA polymerase II
GO:32880; regulation of protein localization
GO:42307; positive regulation of protein import into nucleus
GO:6606; protein import into nucleus
GO:6406; mRNA export from nucleus
GO:90267; positive regulation of mitotic cell cycle spindle assembly checkpoint
GO:90316; positive regulation of intracellular protein transport
GO:7094; mitotic spindle assembly checkpoint signaling
GO:34605; cellular response to heat
GO:1901673; regulation of mitotic spindle assembly
GO:45947; negative regulation of translational initiation
GO:46827; positive regulation of protein export from nucleus
GO:35457; cellular response to interferon-alpha
GO:6404; RNA import into nucleus
GO:6405; RNA export from nucleus
GO:6999; nuclear pore organization
GO:10965; regulation of mitotic sister chromatid separation
GO:31453; positive regulation of heterochromatin assembly
GO:31990; mRNA export from nucleus in response to heat stress
GO:46832; negative regulation of RNA export from nucleus
GO:70849; response to epidermal growth factor
GO:6913; nucleocytoplasmic transport

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5856; cytoskeleton
GO:5635; nuclear envelope
GO:31965; nuclear membrane
GO:5694; chromosome
GO:5643; nuclear pore
GO:775; chromosome, centromeric region
GO:5819; spindle
GO:5868; cytoplasmic dynein complex
GO:776; kinetochore
GO:5654; nucleoplasm
GO:19898; extrinsic component of membrane
GO:72686; mitotic spindle
GO:44615; nuclear pore nuclear basket
GO:42405; nuclear inclusion body
GO:34399; nuclear periphery

Function:

GO:3723; RNA binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:3729; mRNA binding
GO:70840; dynein complex binding
GO:3682; chromatin binding
GO:17056; structural constituent of nuclear pore
GO:15631; tubulin binding
GO:51019; mitogen-activated protein kinase binding
GO:31072; heat shock protein binding

Hide GO terms

Homologs of TPR in Model Organisms

Caenorhabditis elegans: npp-21
Danio rerio: tprb
Drosophila melanogaster: Mtor
Mus musculus: Tpr
Rattus norvegicus: Tpr
Saccharomyces cerevisiae: MLP2
Schizosaccharomyces pombe: nup211

Cell Senescence Entries for TPR

TPR Gene Information

TPR Ontologies

Homologs of TPR in Model Organisms

External links