Cell Senescence Entries for TRA2B

Cell Types
Colon cancer
Cell Lines
HCT116
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Kajita et al. (2016) Ultraconserved region-containing Transformer 2β4 controls senescence of colon cancer cells. Oncogenesis 5(2)e213 (PubMed)

TRA2B Gene Information

HGNC symbol
TRA2B 
Aliases
Htra2-beta; PPP1R156; SFRS10 
Common name
transformer 2 beta homolog 
Entrez Id
6434
Description
This gene encodes a nuclear protein which functions as sequence-specific serine/arginine splicing factor which plays a role in mRNA processing, splicing patterns, and gene expression. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011].

TRA2B Ontologies

Gene Ontology
Process: GO:6397; mRNA processing
GO:8380; RNA splicing
GO:43484; regulation of RNA splicing
GO:398; mRNA splicing, via spliceosome
GO:48026; positive regulation of mRNA splicing, via spliceosome
GO:381; regulation of alternative mRNA splicing, via spliceosome
GO:375; RNA splicing, via transesterification reactions
GO:21796; cerebral cortex regionalization
GO:71333; cellular response to glucose stimulus
GO:1990403; embryonic brain development
Cellular component: GO:5634; nucleus
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5681; spliceosomal complex
GO:5637; nuclear inner membrane
Function: GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:42802; identical protein binding
GO:5515; protein binding
GO:3729; mRNA binding
GO:19904; protein domain specific binding
GO:36002; pre-mRNA binding
Hide GO terms

Homologs of TRA2B in Model Organisms

Danio rerio
tra2b
Drosophila melanogaster
tra2
Mus musculus
Tra2b
Rattus norvegicus
Tra2b

In other databases

CellAge gene expression
  • This gene is present as TRA2B

External links

OMIM
602719
Ensembl
ENSG00000136527
Entrez Gene
6434
UniGene
533122
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TRA2B
GeneCards
TRA2B