Cell Senescence Entries for TRPM7

Cell Types
Pancreatic adenocarcinoma
Cell Lines
BxPC-3, PANC-1
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Yee et al. (2012) Targeted silencing of TRPM7 ion channel induces replicative senescence and produces enhanced cytotoxicity with gemcitabine in pancreatic adenocarcinoma. Cancer Lett 318(1)99-105 (PubMed)

TRPM7 Gene Information

HGNC symbol
TRPM7 
Aliases
CHAK1; LTRPC7; TRP-PLIK 
Common name
transient receptor potential cation channel subfamily M member 7 
Entrez Id
54822
Description
This gene belongs to the melastatin subfamily of transient receptor potential family of ion channels. The protein encoded by this gene is both an ion channel and a serine/threonine protein kinase. The kinase activity is essential for the ion channel function, which serves to increase intracellular calcium levels and to help regulate magnesium ion homeostasis. The encoded protein is involved in cytoskeletal organization, cell adhesion, cell migration and organogenesis. Defects in this gene are a cause of amyotrophic lateral sclerosis-parkinsonism/dementia complex of Guam. The gene may also be associated with defects of cardiac function. [provided by RefSeq, Aug 2017].

TRPM7 Ontologies

Gene Ontology
Process: GO:6468; protein phosphorylation
GO:16310; phosphorylation
GO:6812; cation transport
GO:10961; cellular magnesium ion homeostasis
GO:55085; transmembrane transport
GO:6811; ion transport
GO:12501; programmed cell death
GO:6816; calcium ion transport
GO:16340; calcium-dependent cell-matrix adhesion
GO:30001; metal ion transport
GO:31032; actomyosin structure organization
GO:46777; protein autophosphorylation
GO:51262; protein tetramerization
GO:70588; calcium ion transmembrane transport
GO:70266; necroptotic process
GO:98655; cation transmembrane transport
GO:72507; divalent inorganic cation homeostasis
Cellular component: GO:16021; integral component of membrane
GO:16020; membrane
GO:5886; plasma membrane
GO:1726; ruffle
GO:5887; integral component of plasma membrane
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:106310; protein serine kinase activity
GO:5216; ion channel activity
GO:3779; actin binding
GO:5262; calcium channel activity
GO:17022; myosin binding
GO:5261; cation channel activity
Hide GO terms

Homologs of TRPM7 in Model Organisms

Caenorhabditis elegans
gon-2
Danio rerio
trpm7
Mus musculus
Trpm7
Rattus norvegicus
Trpm7

External links

OMIM
605692
Ensembl
ENSG00000092439
Entrez Gene
54822
UniGene
512894
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TRPM7
GeneCards
TRPM7