Cell Senescence Entries for TRRAP

Cell Types
Melanoma
Cell Lines
A375P
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Cairney et al. (2017) A 'synthetic-sickness' screen for senescence re-engagement targets in mutant cancer backgrounds. PLoS Genet 13(8)e1006942 (PubMed)

TRRAP Gene Information

HGNC symbol
TRRAP 
Aliases
PAF400; TR-AP; Tra1 
Common name
transformation/transcription domain associated protein 
Entrez Id
8295
Description
This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].

TRRAP Ontologies

Gene Ontology
Process: GO:6325; chromatin organization
GO:16573; histone acetylation
GO:16578; histone deubiquitination
GO:6355; regulation of transcription, DNA-templated
GO:43968; histone H2A acetylation
GO:43967; histone H4 acetylation
GO:6357; regulation of transcription by RNA polymerase II
GO:35521; monoubiquitinated histone deubiquitination
GO:35522; monoubiquitinated histone H2A deubiquitination
GO:43966; histone H3 acetylation
GO:45893; positive regulation of transcription, DNA-templated
GO:42981; regulation of apoptotic process
GO:6281; DNA repair
GO:51726; regulation of cell cycle
GO:1905168; positive regulation of double-strand break repair via homologous recombination
GO:2000779; regulation of double-strand break repair
GO:43484; regulation of RNA splicing
GO:6282; regulation of DNA repair
GO:16310; phosphorylation
GO:2000112; regulation of cellular macromolecule biosynthetic process
GO:18193; peptidyl-amino acid modification
Cellular component: GO:5634; nucleus
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:123; histone acetyltransferase complex
GO:124; SAGA complex
GO:35267; NuA4 histone acetyltransferase complex
GO:33276; transcription factor TFTC complex
GO:786; nucleosome
GO:812; Swr1 complex
Function: GO:5515; protein binding
GO:3712; transcription coregulator activity
GO:16301; kinase activity
GO:16740; transferase activity
Hide GO terms

Homologs of TRRAP in Model Organisms

Caenorhabditis elegans
trr-1
Danio rerio
wu:fc54d09
Drosophila melanogaster
Nipped-A
Mus musculus
Trrap
Rattus norvegicus
Trrap
Saccharomyces cerevisiae
TRA1
Schizosaccharomyces pombe
SPAC1F5.11c

External links

OMIM
603015
Ensembl
ENSG00000196367
Entrez Gene
8295
UniGene
203952
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TRRAP
GeneCards
TRRAP