The TSC22D1 gene and its putative association with human ageing

Cell Senescence Entries for TSC22D1

Cell Types: Fibroblast
Cell Lines: TIG-3
Cancer Cell?: No
Method: Knockdown
Type of senescence: Oncogene-induced
Senescence Effect: Inhibits
Primary Reference: Hömig-Hölzel et al. (2011) Antagonistic TSC22D1 variants control BRAF(E600)-induced senescence. EMBO J 30(9)1753-65 (PubMed)

HGNC symbol: TSC22D1
Aliases: MGC17597; TGFB1I4; TSC22
Common name: TSC22 domain family member 1
Entrez Id: 8848
Description: This gene encodes a member of the TSC22 domain family of leucine zipper transcription factors. The encoded protein is stimulated by transforming growth factor beta, and regulates the transcription of multiple genes including C-type natriuretic peptide. The encoded protein may play a critical role in tumor suppression through the induction of cancer cell apoptosis, and a single nucleotide polymorphism in the promoter of this gene has been associated with diabetic nephropathy. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011].

Gene Ontology

Process:

GO:6357; regulation of transcription by RNA polymerase II
GO:6366; transcription by RNA polymerase II

Cellular component:

GO:5634; nucleus
GO:5737; cytoplasm

Function:

GO:5515; protein binding

Hide GO terms

CellAge gene expression