Cell Senescence Entries for TWIST2

Cell Types
Cervical cancer
Cell Lines
HeLa, SiHa
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Wang et al. (2014) Twist2, the key Twist isoform related to prognosis, promotes invasion of cervical cancer by inducing epithelial-mesenchymal transition and blocking senescence. Hum Pathol 45(9)1839-46 (PubMed)

TWIST2 Gene Information

HGNC symbol
TWIST2 
Aliases
bHLHa39; Dermo-1; DERMO1 
Common name
twist family bHLH transcription factor 2 
Entrez Id
117581
Description
The protein encoded by this gene is a basic helix-loop-helix type transcription factor and shares similarity with Twist. This protein may inhibit osteoblast maturation and maintain cells in a preosteoblast phenotype during osteoblast development. This gene may be upregulated in certain cancers. Mutations in this gene cause focal facial dermal dysplasia 3, Setleis type. Two transcript variants encoding the same protein have been found. [provided by RefSeq, Apr 2014].

TWIST2 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:6357; regulation of transcription by RNA polymerase II
GO:32502; developmental process
GO:30335; positive regulation of cell migration
GO:45668; negative regulation of osteoblast differentiation
GO:43066; negative regulation of apoptotic process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5730; nucleolus
Function: GO:3677; DNA binding
GO:46983; protein dimerization activity
GO:5515; protein binding
GO:977; RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
Hide GO terms

Homologs of TWIST2 in Model Organisms

Danio rerio
twist2
Drosophila melanogaster
amos
Mus musculus
Twist2
Rattus norvegicus
Twist2

External links

OMIM
607556
Ensembl
ENSG00000233608
Entrez Gene
117581
UniGene
745035
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TWIST2
GeneCards
TWIST2