Cell Senescence Entries for TXN

Cell Types
Foreskin fibroblast
Cell Lines
BJ, BJE-LT
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Young et al. (2010) Suppression of thioredoxin-1 induces premature senescence in normal human fibroblasts. Biochem Biophys Res Commun 392(3)363-8 (PubMed)

TXN Gene Information

HGNC symbol
TXN 
Aliases
TRX; Trx80 
Common name
thioredoxin 
Entrez Id
7295
Description
The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

TXN Ontologies

Gene Ontology
Process: GO:98869; cellular oxidant detoxification
GO:51897; positive regulation of protein kinase B signaling
GO:45454; cell redox homeostasis
GO:1903206; negative regulation of hydrogen peroxide-induced cell death
GO:9314; response to radiation
GO:43388; positive regulation of DNA binding
GO:32148; activation of protein kinase B activity
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:71731; response to nitric oxide
GO:2000170; positive regulation of peptidyl-cysteine S-nitrosylation
GO:122; negative regulation of transcription by RNA polymerase II
GO:46826; negative regulation of protein export from nucleus
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5576; extracellular region
GO:70062; extracellular exosome
Function: GO:3723; RNA binding
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:15035; protein-disulfide reductase activity
GO:4791; thioredoxin-disulfide reductase activity
GO:47134; protein-disulfide reductase (NAD(P)) activity
Hide GO terms

Homologs of TXN in Model Organisms

Danio rerio
zgc:56493
Drosophila melanogaster
TrxT
Mus musculus
Txn
Rattus norvegicus
Txn
Saccharomyces cerevisiae
TRX1
Schizosaccharomyces pombe
trx1

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as TrxT
  • A homolog of this gene for Mus musculus is present as Txn1
  • A homolog of this gene for Saccharomyces cerevisiae is present as TRX1
GenAge human genes
  • This gene is present as TXN

External links

OMIM
187700
Ensembl
ENSG00000136810
Entrez Gene
7295
UniGene
435136
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TXN
GeneCards
TXN