Cell Senescence Entries for TYMS

Cell Types
Melanoma
Cell Lines
SK-MEL-19, SK-MEL-29
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Mannava et al. (2013) Ribonucleotide reductase and thymidylate synthase or exogenous deoxyribonucleosides reduce DNA damage and senescence caused by C-MYC depletion. Aging (Albany NY) 4(12)917-22 (PubMed)

TYMS Gene Information

HGNC symbol
TYMS 
Aliases
HsT422; TMS; TS; Tsase 
Common name
thymidylate synthetase 
Entrez Id
7298
Description
Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using, 10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occurring antisense transcript, mitochondrial enolase superfamily member 1 (GeneID:55556), vary inversely when cell-growth progresses from late-log to plateau phase. Polymorphisms in this gene may be associated with etiology of neoplasia, including breast cancer, and response to chemotherapy. [provided by RefSeq, Aug 2017].

TYMS Ontologies

Gene Ontology
Process: GO:71897; DNA biosynthetic process
GO:32259; methylation
GO:9165; nucleotide biosynthetic process
GO:46683; response to organophosphorus
GO:17148; negative regulation of translation
GO:6206; pyrimidine nucleobase metabolic process
GO:6231; dTMP biosynthetic process
GO:6235; dTTP biosynthetic process
GO:6417; regulation of translation
GO:7568; aging
GO:7623; circadian rhythm
GO:9410; response to xenobiotic stimulus
GO:9636; response to toxic substance
GO:14070; response to organic cyclic compound
GO:19860; uracil metabolic process
GO:32570; response to progesterone
GO:33189; response to vitamin A
GO:34097; response to cytokine
GO:35999; tetrahydrofolate interconversion
GO:45471; response to ethanol
GO:46653; tetrahydrofolate metabolic process
GO:48589; developmental growth
GO:51216; cartilage development
GO:51384; response to glucocorticoid
GO:51593; response to folic acid
GO:60574; intestinal epithelial cell maturation
GO:97421; liver regeneration
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:5739; mitochondrion
GO:5743; mitochondrial inner membrane
GO:5759; mitochondrial matrix
GO:5829; cytosol
GO:5730; nucleolus
Function: GO:16740; transferase activity
GO:8168; methyltransferase activity
GO:3824; catalytic activity
GO:900; translation repressor activity, mRNA regulatory element binding
GO:5542; folic acid binding
GO:1990825; sequence-specific mRNA binding
GO:3729; mRNA binding
GO:4799; thymidylate synthase activity
GO:16741; transferase activity, transferring one-carbon groups
GO:42803; protein homodimerization activity
GO:1901363; heterocyclic compound binding
Hide GO terms

Homologs of TYMS in Model Organisms

Caenorhabditis elegans
CELE_Y110A7A.4
Danio rerio
tyms
Drosophila melanogaster
Ts
Mus musculus
Tyms
Rattus norvegicus
Tyms
Saccharomyces cerevisiae
CDC21

In other databases

CellAge gene expression
  • This gene is present as TYMS

External links

OMIM
188350
Ensembl
ENSG00000176890
Entrez Gene
7298
UniGene
369762
1000 Genomes
1000 Genomes
HPRD
GenAtlas
TYMS
GeneCards
TYMS