Cell Senescence Entries for UBE2C

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Guo et al. (2021) Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression. Oncogenesis 7(6)49 (PubMed)

UBE2C Gene Information

HGNC symbol
UBE2C 
Aliases
UBCH10 
Common name
ubiquitin conjugating enzyme E2 C 
Entrez Id
11065
Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, ubiquitin-conjugating enzymes, and ubiquitin-protein ligases. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. The encoded protein is required for the destruction of mitotic cyclins and for cell cycle progression, and may be involved in cancer progression. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been defined on chromosomes 4, 14, 15, 18, and 19. [provided by RefSeq, Aug 2013].

UBE2C Ontologies

Gene Ontology
Process: GO:7049; cell cycle
GO:16567; protein ubiquitination
GO:51301; cell division
GO:6511; ubiquitin-dependent protein catabolic process
GO:31145; anaphase-promoting complex-dependent catabolic process
GO:209; protein polyubiquitination
GO:70936; protein K48-linked ubiquitination
GO:10458; exit from mitosis
GO:10994; free ubiquitin chain polymerization
GO:30071; regulation of mitotic metaphase/anaphase transition
GO:31536; positive regulation of exit from mitosis
GO:70979; protein K11-linked ubiquitination
GO:1904668; positive regulation of ubiquitin protein ligase activity
GO:32446; protein modification by small protein conjugation
Cellular component: GO:5829; cytosol
GO:5886; plasma membrane
GO:5634; nucleus
GO:5654; nucleoplasm
GO:151; ubiquitin ligase complex
GO:5680; anaphase-promoting complex
Function: GO:166; nucleotide binding
GO:5524; ATP binding
GO:16740; transferase activity
GO:5515; protein binding
GO:4842; ubiquitin-protein transferase activity
GO:61631; ubiquitin conjugating enzyme activity
GO:61630; ubiquitin protein ligase activity
GO:44389; ubiquitin-like protein ligase binding
GO:19787; ubiquitin-like protein transferase activity
Hide GO terms

Homologs of UBE2C in Model Organisms

Drosophila melanogaster
vih
Mus musculus
Ube2c
Rattus norvegicus
Ube2c
Saccharomyces cerevisiae
UBC11
Schizosaccharomyces pombe
ubc11

In other databases

CellAge gene expression
  • This gene is present as UBE2C

External links

OMIM
605574
Ensembl
ENSG00000175063
Entrez Gene
11065
UniGene
93002
1000 Genomes
1000 Genomes
HPRD
GenAtlas
UBE2C
GeneCards
UBE2C