Cell Senescence Entries for UBE2I
- Cell Types
- Osteosarcoma
- Cell Lines
- U2OS
- Cancer Cell?
- Yes
- Method
- Mutation, Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- McManus et al. (2019) Quantitative SUMO proteomics reveals the modulation of several PML nuclear body associated proteins and an anti-senescence function of UBC9. Sci Rep 8(1)7754 (PubMed)
UBE2I Gene Information
- HGNC symbol
- UBE2I
- Aliases
- UBC9
- Common name
- ubiquitin conjugating enzyme E2 I
- Entrez Id
- 7329
- Description
- The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Four alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008].
UBE2I Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:51301; cell division
GO:16925; protein sumoylation
GO:7059; chromosome segregation
GO:122; negative regulation of transcription by RNA polymerase II
GO:6464; cellular protein modification process
GO:45892; negative regulation of transcription, DNA-templated
GO:6511; ubiquitin-dependent protein catabolic process
GO:7084; mitotic nuclear membrane reassembly
GO:1903755; positive regulation of SUMO transferase activity
GO:51168; nuclear export
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:32446; protein modification by small protein conjugation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16605; PML body
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5635; nuclear envelope
GO:5643; nuclear pore
GO:106068; SUMO ligase complex
GO:795; synaptonemal complex
GO:1990234; transferase complex
GO:1990356; sumoylated E2 ligase complex
GO:16604; nuclear body
Hide GO termsFunction: GO:5515; protein binding
GO:3723; RNA binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:16740; transferase activity
GO:19899; enzyme binding
GO:19789; SUMO transferase activity
GO:8134; transcription factor binding
GO:1221; transcription coregulator binding
GO:71535; RING-like zinc finger domain binding
GO:44388; small protein activating enzyme binding
GO:61656; SUMO conjugating enzyme activity
GO:43398; HLH domain binding
GO:19787; ubiquitin-like protein transferase activity
Homologs of UBE2I in Model Organisms
- Caenorhabditis elegans
- ubc-9
- Danio rerio
- ube2ib
- Drosophila melanogaster
- lwr
- Mus musculus
- Ube2i
- Rattus norvegicus
- Ube2i
- Saccharomyces cerevisiae
- UBC9
- Schizosaccharomyces pombe
- hus5
In other databases
- GenAge human genes
- This gene is present as UBE2I
External links
- OMIM
- 601661
- Ensembl
- ENSG00000103275
- Entrez Gene
- 7329
- UniGene
- 302903
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- UBE2I
- GeneCards
- UBE2I