Cell Senescence Entries for UBE2N

Cell Types
Melanoma
Cell Lines
A2058, A375
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Dikshit et al. (2019) UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling. Cancer Res 78(22)6462-6472 (PubMed)

UBE2N Gene Information

HGNC symbol
UBE2N 
Aliases
MGC8489; UBC13; UbcH-ben 
Common name
ubiquitin conjugating enzyme E2 N 
Entrez Id
7334
Description
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008].

UBE2N Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:32446; protein modification by small protein conjugation
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:50852; T cell receptor signaling pathway
GO:209; protein polyubiquitination
GO:70534; protein K63-linked ubiquitination
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:724; double-strand break repair via homologous recombination
GO:6301; postreplication repair
GO:729; DNA double-strand break processing
GO:6282; regulation of DNA repair
GO:6511; ubiquitin-dependent protein catabolic process
GO:16574; histone ubiquitination
GO:31058; positive regulation of histone modification
GO:33182; regulation of histone ubiquitination
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:45739; positive regulation of DNA repair
GO:51443; positive regulation of ubiquitin-protein transferase activity
GO:1902523; positive regulation of protein K63-linked ubiquitination
GO:1902533; positive regulation of intracellular signal transduction
GO:2000781; positive regulation of double-strand break repair
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:1650; fibrillar center
GO:5829; cytosol
GO:70062; extracellular exosome
GO:32991; protein-containing complex
GO:151; ubiquitin ligase complex
GO:31372; UBC13-MMS2 complex
GO:35370; UBC13-UEV1A complex
Function: GO:3723; RNA binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:16740; transferase activity
GO:31625; ubiquitin protein ligase binding
GO:19787; ubiquitin-like protein transferase activity
GO:5515; protein binding
GO:4842; ubiquitin-protein transferase activity
GO:61631; ubiquitin conjugating enzyme activity
GO:43130; ubiquitin binding
Hide GO terms

Homologs of UBE2N in Model Organisms

Danio rerio
ube2nb
Mus musculus
Ube2n
Rattus norvegicus
Ube2n

External links

OMIM
603679
Ensembl
ENSG00000177889
Entrez Gene
7334
UniGene
524630
1000 Genomes
1000 Genomes
HPRD
GenAtlas
UBE2N
GeneCards
UBE2N