Cell Senescence Entries for UBE2V1

Cell Types
Melanoma
Cell Lines
A2058, A375
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Dikshit et al. (2019) UBE2N Promotes Melanoma Growth via MEK/FRA1/SOX10 Signaling. Cancer Res 78(22)6462-6472 (PubMed)

UBE2V1 Gene Information

HGNC symbol
UBE2V1 
Aliases
CROC-1; CROC1; UBE2V; UEV-1; UEV1A 
Common name
ubiquitin conjugating enzyme E2 V1 
Entrez Id
7335
Description
Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012].

UBE2V1 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:45893; positive regulation of transcription, DNA-templated
GO:209; protein polyubiquitination
GO:70534; protein K63-linked ubiquitination
GO:6282; regulation of DNA repair
GO:6301; postreplication repair
GO:43123; positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:1902523; positive regulation of protein K63-linked ubiquitination
GO:1902533; positive regulation of intracellular signal transduction
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5829; cytosol
GO:70062; extracellular exosome
GO:32991; protein-containing complex
GO:5737; cytoplasm
GO:151; ubiquitin ligase complex
GO:35370; UBC13-UEV1A complex
GO:31371; ubiquitin conjugating enzyme complex
Function: GO:5515; protein binding
Hide GO terms

Homologs of UBE2V1 in Model Organisms

Danio rerio
ube2v1
Mus musculus
Gm8325
Rattus norvegicus
LOC100912618
Saccharomyces cerevisiae
MMS2

External links

OMIM
602995
Ensembl
ENSG00000244687
Entrez Gene
7335
UniGene
744839
1000 Genomes
1000 Genomes
HPRD
GenAtlas
UBE2V1
GeneCards
UBE2V1