Cell Senescence Entries for UBE3A

Cell Types
Lymphoma
Cell Lines
LS-92
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Wolyniec et al. (2012) E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis. Blood 120(4)822-32 (PubMed)

UBE3A Gene Information

HGNC symbol
UBE3A 
Aliases
ANCR; AS; E6-AP; EPVE6AP; FLJ26981; HPVE6A 
Common name
ubiquitin protein ligase E3A 
Entrez Id
7337
Description
This gene encodes an E3 ubiquitin-protein ligase, part of the ubiquitin protein degradation system. This imprinted gene is maternally expressed in brain and biallelically expressed in other tissues. Maternally inherited deletion of this gene causes Angelman Syndrome, characterized by severe motor and intellectual retardation, ataxia, hypotonia, epilepsy, absence of speech, and characteristic facies. The protein also interacts with the E6 protein of human papillomavirus types 16 and 18, resulting in ubiquitination and proteolysis of tumor protein p53. Alternative splicing of this gene results in three transcript variants encoding three isoforms with different N-termini. Additional transcript variants have been described, but their full length nature has not been determined. [provided by RefSeq, Jul 2008].

UBE3A Ontologies

Gene Ontology
Process: GO:16567; protein ubiquitination
GO:6511; ubiquitin-dependent protein catabolic process
GO:48511; rhythmic process
GO:70936; protein K48-linked ubiquitination
GO:51865; protein autoubiquitination
GO:7420; brain development
GO:42752; regulation of circadian rhythm
GO:6508; proteolysis
GO:2000058; regulation of ubiquitin-dependent protein catabolic process
GO:32570; response to progesterone
GO:50847; progesterone receptor signaling pathway
GO:31398; positive regulation of protein ubiquitination
GO:1541; ovarian follicle development
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:30521; androgen receptor signaling pathway
GO:35037; sperm entry
GO:45944; positive regulation of transcription by RNA polymerase II
GO:60736; prostate gland growth
GO:1905528; positive regulation of Golgi lumen acidification
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5829; cytosol
GO:502; proteasome complex
Function: GO:4842; ubiquitin-protein transferase activity
GO:46872; metal ion binding
GO:16740; transferase activity
GO:16874; ligase activity
GO:5515; protein binding
GO:61630; ubiquitin protein ligase activity
GO:3713; transcription coactivator activity
Hide GO terms

Homologs of UBE3A in Model Organisms

Danio rerio
ube3a
Drosophila melanogaster
Ube3a
Mus musculus
Ube3a
Rattus norvegicus
Ube3a

External links

OMIM
601623
Ensembl
ENSG00000114062
Entrez Gene
7337
UniGene
598862
1000 Genomes
1000 Genomes
HPRD
GenAtlas
UBE3A
GeneCards
UBE3A