Cell Senescence Entries for VDR

Cell Types
Foreskin fibroblast
Cell Lines
BJ
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Graziano et al. (2017) Vitamin D/vitamin D receptor axis regulates DNA repair during oncogene-induced senescence. Oncogene 35(41)5362-5376 (PubMed)

VDR Gene Information

HGNC symbol
VDR 
Aliases
NR1I1; PPP1R163 
Common name
vitamin D receptor 
Entrez Id
7421
Description
This gene encodes vitamin D3 receptor, which is a member of the nuclear hormone receptor superfamily of ligand-inducible transcription factors. This receptor also functions as a receptor for the secondary bile acid, lithocholic acid. Downstream targets of vitamin D3 receptor are principally involved in mineral metabolism, though this receptor regulates a variety of other metabolic pathways, such as those involved in immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Jun 2018].

VDR Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:45944; positive regulation of transcription by RNA polymerase II
GO:30522; intracellular receptor signaling pathway
GO:122; negative regulation of transcription by RNA polymerase II
GO:30154; cell differentiation
GO:10628; positive regulation of gene expression
GO:1501; skeletal system development
GO:6816; calcium ion transport
GO:6874; cellular calcium ion homeostasis
GO:7595; lactation
GO:9887; animal organ morphogenesis
GO:50892; intestinal absorption
GO:60058; positive regulation of apoptotic process involved in mammary gland involution
GO:60558; regulation of calcidiol 1-monooxygenase activity
GO:60745; mammary gland branching involved in pregnancy
GO:42789; mRNA transcription by RNA polymerase II
GO:8285; negative regulation of cell population proliferation
GO:10980; positive regulation of vitamin D 24-hydroxylase activity
GO:46697; decidualization
GO:45618; positive regulation of keratinocyte differentiation
GO:45892; negative regulation of transcription, DNA-templated
GO:902; cell morphogenesis
GO:10839; negative regulation of keratinocyte proliferation
GO:38183; bile acid signaling pathway
GO:70561; vitamin D receptor signaling pathway
GO:70564; positive regulation of vitamin D receptor signaling pathway
GO:30501; positive regulation of bone mineralization
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:785; chromatin
GO:90575; RNA polymerase II transcription regulator complex
GO:43235; receptor complex
Function: GO:5515; protein binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:4879; nuclear receptor activity
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:46965; retinoid X receptor binding
GO:70644; vitamin D response element binding
GO:38186; lithocholic acid receptor activity
GO:1902098; calcitriol binding
GO:1902121; lithocholic acid binding
Hide GO terms

Homologs of VDR in Model Organisms

Danio rerio
vdrb
Mus musculus
Vdr
Rattus norvegicus
Vdr

In other databases

LongevityMap
  • This gene is present as VDR

External links

OMIM
601769
Ensembl
ENSG00000111424
Entrez Gene
7421
UniGene
524368
1000 Genomes
1000 Genomes
HPRD
GenAtlas
VDR
GeneCards
VDR