Cell Senescence Entries for VENTX
- Cell Types
- Cervical cancer, Embryonic kidney, Lung fibroblast, Lymphoblastic leukemia, Osteosarcoma
- Cell Lines
- HEK293T, HeLa, IMR-90, Nalm16, U2OS
- Cancer Cell?
- Yes
- Method
- Knockdown, Overexpression
- Type of senescence
- Unclear
- Senescence Effect
- Induces
- Primary Reference
- Wu et al. (2011) VentX trans-activates p53 and p16ink4a to regulate cellular senescence. J Biol Chem 286(14)12693-701 (PubMed)
VENTX Gene Information
- HGNC symbol
- VENTX
- Aliases
- HPX42B; VENTX2
- Common name
- VENT homeobox
- Entrez Id
- 27287
- Description
- This gene encodes a member of the Vent family of homeodomain proteins. The encoded protein may function as a transcriptional repressor and be involved in mesodermal patterning and hemopoietic stem cell maintenance. Multiple pseudogenes exist for this gene. A transcribed pseudogene located on chromosome X may lead to antigen production in certain melanomas. [provided by RefSeq, Jul 2008].
VENTX Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
Cellular component: GO:5634; nucleus
GO:785; chromatin
GO:5654; nucleoplasm
Hide GO termsFunction: GO:3677; DNA binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43565; sequence-specific DNA binding
Homologs of VENTX in Model Organisms
- Danio rerio
- vox
External links
- OMIM
- 607158
- Ensembl
- ENSG00000151650
- Entrez Gene
- 27287
- UniGene
- 125231
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- VENTX
- GeneCards
- VENTX