Cell Senescence Entries for WNT2

Cell Types
Lung fibroblast
Cell Lines
WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Ye et al. (2007) Downregulation of Wnt signaling is a trigger for formation of facultative heterochromatin and onset of cell senescence in primary human cells. Mol Cell 27(2)183-196 (PubMed)

WNT2 Gene Information

HGNC symbol
WNT2 
Aliases
INT1L1; IRP 
Common name
Wnt family member 2 
Entrez Id
7472
Description
This gene is a member of the WNT gene family. The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jul 2008].

WNT2 Ontologies

Gene Ontology
Process: GO:16055; Wnt signaling pathway
GO:1938; positive regulation of endothelial cell proliferation
GO:2053; positive regulation of mesenchymal cell proliferation
GO:30324; lung development
GO:33278; cell proliferation in midbrain
GO:45944; positive regulation of transcription by RNA polymerase II
GO:50769; positive regulation of neurogenesis
GO:55009; atrial cardiac muscle tissue morphogenesis
GO:60045; positive regulation of cardiac muscle cell proliferation
GO:60070; canonical Wnt signaling pathway
GO:60317; cardiac epithelial to mesenchymal transition
GO:60492; lung induction
GO:60501; positive regulation of epithelial cell proliferation involved in lung morphogenesis
GO:60716; labyrinthine layer blood vessel development
GO:8284; positive regulation of cell population proliferation
GO:30182; neuron differentiation
GO:71300; cellular response to retinoic acid
GO:71560; cellular response to transforming growth factor beta stimulus
GO:51091; positive regulation of DNA-binding transcription factor activity
GO:45165; cell fate commitment
GO:61072; iris morphogenesis
GO:1904948; midbrain dopaminergic neuron differentiation
GO:7267; cell-cell signaling
GO:48146; positive regulation of fibroblast proliferation
GO:1904954; canonical Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:2088; lens development in camera-type eye
GO:22008; neurogenesis
GO:61180; mammary gland epithelium development
GO:7275; multicellular organism development
Cellular component: GO:5737; cytoplasm
GO:5576; extracellular region
GO:5615; extracellular space
GO:62023; collagen-containing extracellular matrix
GO:1990909; Wnt signalosome
GO:31232; extrinsic component of external side of plasma membrane
Function: GO:5515; protein binding
GO:5102; signaling receptor binding
GO:5125; cytokine activity
GO:5109; frizzled binding
GO:48018; receptor ligand activity
Hide GO terms

Homologs of WNT2 in Model Organisms

Mus musculus
Wnt2
Rattus norvegicus
Wnt2

External links

OMIM
147870
Ensembl
ENSG00000105989
Entrez Gene
7472
UniGene
567356
1000 Genomes
1000 Genomes
HPRD
GenAtlas
WNT2
GeneCards
WNT2