Cell Senescence Entries for WNT5A

Cell Types
Ovarian cancer
Cell Lines
OVCAR5, PEO1
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Oncogene-induced
Senescence Effect
Induces
Primary Reference
Bitler et al. (2011) Wnt5a suppresses epithelial ovarian cancer by promoting cellular senescence. Cancer Res 71(19)6184-94 (PubMed)

WNT5A Gene Information

HGNC symbol
WNT5A 
Aliases
hWNT5A 
Common name
Wnt family member 5A 
Entrez Id
7474
Description
The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012].

WNT5A Ontologies

Gene Ontology
Process: GO:43066; negative regulation of apoptotic process
GO:45892; negative regulation of transcription, DNA-templated
GO:30154; cell differentiation
GO:16055; Wnt signaling pathway
GO:45893; positive regulation of transcription, DNA-templated
GO:10033; response to organic substance
GO:51216; cartilage development
GO:1667; ameboidal-type cell migration
GO:1736; establishment of planar polarity
GO:1756; somitogenesis
GO:1819; positive regulation of cytokine production
GO:1822; kidney development
GO:1843; neural tube closure
GO:1934; positive regulation of protein phosphorylation
GO:1947; heart looping
GO:2009; morphogenesis of an epithelium
GO:2053; positive regulation of mesenchymal cell proliferation
GO:3138; primary heart field specification
GO:3139; secondary heart field specification
GO:3281; ventricular septum development
GO:3283; atrial septum development
GO:3323; type B pancreatic cell development
GO:3344; pericardium morphogenesis
GO:3401; axis elongation
GO:3402; planar cell polarity pathway involved in axis elongation
GO:6468; protein phosphorylation
GO:7223; Wnt signaling pathway, calcium modulating pathway
GO:7254; JNK cascade
GO:7368; determination of left/right symmetry
GO:7409; axonogenesis
GO:7411; axon guidance
GO:7442; hindgut morphogenesis
GO:7494; midgut development
GO:8284; positive regulation of cell population proliferation
GO:8584; male gonad development
GO:8595; anterior/posterior axis specification, embryo
GO:9952; anterior/posterior pattern specification
GO:10628; positive regulation of gene expression
GO:10800; positive regulation of peptidyl-threonine phosphorylation
GO:10976; positive regulation of neuron projection development
GO:16477; cell migration
GO:21891; olfactory bulb interneuron development
GO:21915; neural tube development
GO:22008; neurogenesis
GO:30324; lung development
GO:30326; embryonic limb morphogenesis
GO:30514; negative regulation of BMP signaling pathway
GO:30901; midbrain development
GO:32092; positive regulation of protein binding
GO:32729; positive regulation of interferon-gamma production
GO:32731; positive regulation of interleukin-1 beta production
GO:32755; positive regulation of interleukin-6 production
GO:32757; positive regulation of interleukin-8 production
GO:32760; positive regulation of tumor necrosis factor production
GO:32880; regulation of protein localization
GO:33138; positive regulation of peptidyl-serine phosphorylation
GO:34613; cellular protein localization
GO:35108; limb morphogenesis
GO:35567; non-canonical Wnt signaling pathway
GO:36342; post-anal tail morphogenesis
GO:36517; chemoattraction of serotonergic neuron axon
GO:36518; chemorepulsion of dopaminergic neuron axon
GO:38031; non-canonical Wnt signaling pathway via JNK cascade
GO:40037; negative regulation of fibroblast growth factor receptor signaling pathway
GO:42472; inner ear morphogenesis
GO:42733; embryonic digit morphogenesis
GO:43122; regulation of I-kappaB kinase/NF-kappaB signaling
GO:43507; positive regulation of JUN kinase activity
GO:43547; positive regulation of GTPase activity
GO:45198; establishment of epithelial cell apical/basal polarity
GO:45807; positive regulation of endocytosis
GO:45836; positive regulation of meiotic nuclear division
GO:45860; positive regulation of protein kinase activity
GO:46330; positive regulation of JNK cascade
GO:46546; development of primary male sexual characteristics
GO:48022; negative regulation of melanin biosynthetic process
GO:48341; paraxial mesoderm formation
GO:48546; digestive tract morphogenesis
GO:48570; notochord morphogenesis
GO:48812; neuron projection morphogenesis
GO:48843; negative regulation of axon extension involved in axon guidance
GO:48850; hypophysis morphogenesis
GO:50679; positive regulation of epithelial cell proliferation
GO:50680; negative regulation of epithelial cell proliferation
GO:50919; negative chemotaxis
GO:51885; positive regulation of timing of anagen
GO:51964; negative regulation of synapse assembly
GO:60026; convergent extension
GO:60028; convergent extension involved in axis elongation
GO:60029; convergent extension involved in organogenesis
GO:60065; uterus development
GO:60067; cervix development
GO:60068; vagina development
GO:60070; canonical Wnt signaling pathway
GO:60071; Wnt signaling pathway, planar cell polarity pathway
GO:60157; urinary bladder development
GO:60599; lateral sprouting involved in mammary gland duct morphogenesis
GO:60606; tube closure
GO:60638; mesenchymal-epithelial cell signaling
GO:60686; negative regulation of prostatic bud formation
GO:60744; mammary gland branching involved in thelarche
GO:60750; epithelial cell proliferation involved in mammary gland duct elongation
GO:60762; regulation of branching involved in mammary gland duct morphogenesis
GO:60775; planar cell polarity pathway involved in gastrula mediolateral intercalation
GO:60809; mesodermal to mesenchymal transition involved in gastrulation
GO:61036; positive regulation of cartilage development
GO:61053; somite development
GO:61347; planar cell polarity pathway involved in outflow tract morphogenesis
GO:61348; planar cell polarity pathway involved in ventricular septum morphogenesis
GO:61349; planar cell polarity pathway involved in cardiac right atrium morphogenesis
GO:61350; planar cell polarity pathway involved in cardiac muscle tissue morphogenesis
GO:61354; planar cell polarity pathway involved in pericardium morphogenesis
GO:70245; positive regulation of thymocyte apoptotic process
GO:71219; cellular response to molecule of bacterial origin
GO:71425; hematopoietic stem cell proliferation
GO:71542; dopaminergic neuron differentiation
GO:90009; primitive streak formation
GO:90082; positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
GO:90090; negative regulation of canonical Wnt signaling pathway
GO:90103; cochlea morphogenesis
GO:90179; planar cell polarity pathway involved in neural tube closure
GO:90630; activation of GTPase activity
GO:97325; melanocyte proliferation
GO:150012; positive regulation of neuron projection arborization
GO:1901216; positive regulation of neuron death
GO:1904934; negative regulation of cell proliferation in midbrain
GO:1904938; planar cell polarity pathway involved in axon guidance
GO:1904948; midbrain dopaminergic neuron differentiation
GO:1904953; Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation
GO:2000049; positive regulation of cell-cell adhesion mediated by cadherin
GO:2000052; positive regulation of non-canonical Wnt signaling pathway
GO:71222; cellular response to lipopolysaccharide
GO:71346; cellular response to interferon-gamma
GO:30182; neuron differentiation
GO:71300; cellular response to retinoic acid
GO:45944; positive regulation of transcription by RNA polymerase II
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:50729; positive regulation of inflammatory response
GO:71560; cellular response to transforming growth factor beta stimulus
GO:45165; cell fate commitment
GO:45599; negative regulation of fat cell differentiation
GO:62009; secondary palate development
GO:99054; presynapse assembly
GO:99068; postsynapse assembly
GO:1904861; excitatory synapse assembly
GO:45766; positive regulation of angiogenesis
GO:10595; positive regulation of endothelial cell migration
GO:2720; positive regulation of cytokine production involved in immune response
GO:32722; positive regulation of chemokine production
GO:42060; wound healing
GO:48146; positive regulation of fibroblast proliferation
GO:32148; activation of protein kinase B activity
GO:71277; cellular response to calcium ion
GO:45732; positive regulation of protein catabolic process
GO:1938; positive regulation of endothelial cell proliferation
GO:60907; positive regulation of macrophage cytokine production
GO:99175; regulation of postsynapse organization
GO:43032; positive regulation of macrophage activation
GO:60760; positive regulation of response to cytokine stimulus
GO:1837; epithelial to mesenchymal transition
GO:90037; positive regulation of protein kinase C signaling
GO:48706; embryonic skeletal system development
GO:2088; lens development in camera-type eye
GO:1902474; positive regulation of protein localization to synapse
GO:30216; keratinocyte differentiation
GO:10820; positive regulation of T cell chemotaxis
GO:3408; optic cup formation involved in camera-type eye development
GO:45778; positive regulation of ossification
GO:48806; genitalia development
GO:50727; regulation of inflammatory response
GO:50807; regulation of synapse organization
GO:60324; face development
GO:60340; positive regulation of type I interferon-mediated signaling pathway
GO:72201; negative regulation of mesenchymal cell proliferation
GO:99566; regulation of postsynaptic cytosolic calcium ion concentration
GO:1900020; positive regulation of protein kinase C activity
GO:1904862; inhibitory synapse assembly
GO:1904955; planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation
GO:7275; multicellular organism development
Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:5886; plasma membrane
GO:98794; postsynapse
GO:9986; cell surface
GO:31012; extracellular matrix
GO:62023; collagen-containing extracellular matrix
GO:5788; endoplasmic reticulum lumen
GO:30666; endocytic vesicle membrane
GO:5796; Golgi lumen
GO:98978; glutamatergic synapse
GO:70062; extracellular exosome
GO:30669; clathrin-coated endocytic vesicle membrane
Function: GO:5102; signaling receptor binding
GO:5515; protein binding
GO:5109; frizzled binding
GO:5125; cytokine activity
GO:19904; protein domain specific binding
GO:1902379; chemoattractant activity involved in axon guidance
GO:48018; receptor ligand activity
GO:5115; receptor tyrosine kinase-like orphan receptor binding
GO:5543; phospholipid binding
Hide GO terms

Homologs of WNT5A in Model Organisms

Caenorhabditis elegans
wnt-2
Danio rerio
wnt5b
Mus musculus
Wnt5a
Rattus norvegicus
Wnt5a

In other databases

CellAge gene expression
  • This gene is present as WNT5A

External links

OMIM
164975
Ensembl
ENSG00000114251
Entrez Gene
7474
UniGene
643085
1000 Genomes
1000 Genomes
HPRD
GenAtlas
WNT5A
GeneCards
WNT5A