Cell Senescence Entries for WRN

Cell Types
Fibroblast, WRN syndrome fibroblast
Cell Lines
AG00780, AG03141
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Grandori et al. (2003) Werner syndrome protein limits MYC-induced cellular senescence. Genes Dev 17(13)1569-74 (PubMed)

WRN Gene Information

HGNC symbol
WRN 
Aliases
RECQ3; RECQL2 
Common name
WRN RecQ like helicase 
Entrez Id
7486
Description
This gene encodes a member of the RecQ subfamily of DNA helicase proteins. The encoded nuclear protein is important in the maintenance of genome stability and plays a role in DNA repair, replication, transcription and telomere maintenance. This protein contains a N-terminal 3' to 5' exonuclease domain, an ATP-dependent helicase domain and RQC (RecQ helicase conserved region) domain in its central region, and a C-terminal HRDC (helicase RNase D C-terminal) domain and nuclear localization signal. Defects in this gene are the cause of Werner syndrome, an autosomal recessive disorder characterized by accelerated aging and an elevated risk for certain cancers. [provided by RefSeq, Aug 2017].

WRN Ontologies

Gene Ontology
Process: GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:8152; metabolic process
GO:6260; DNA replication
GO:6302; double-strand break repair
GO:6310; DNA recombination
GO:731; DNA synthesis involved in DNA repair
GO:6139; nucleobase-containing compound metabolic process
GO:6259; DNA metabolic process
GO:723; telomere maintenance
GO:6284; base-excision repair
GO:31297; replication fork processing
GO:6979; response to oxidative stress
GO:42981; regulation of apoptotic process
GO:7569; cell aging
GO:724; double-strand break repair via homologous recombination
GO:90656; t-circle formation
GO:32508; DNA duplex unwinding
GO:6268; DNA unwinding involved in DNA replication
GO:61820; telomeric D-loop disassembly
GO:7568; aging
GO:71480; cellular response to gamma radiation
GO:10225; response to UV-C
GO:44806; G-quadruplex DNA unwinding
GO:32201; telomere maintenance via semi-conservative replication
GO:9267; cellular response to starvation
GO:1902570; protein localization to nucleolus
GO:7420; brain development
GO:10259; multicellular organism aging
GO:40009; regulation of growth rate
GO:51345; positive regulation of hydrolase activity
GO:90399; replicative senescence
GO:98530; positive regulation of strand invasion
GO:44237; cellular metabolic process
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:16607; nuclear speck
GO:5694; chromosome
GO:5730; nucleolus
GO:5654; nucleoplasm
GO:5737; cytoplasm
GO:5813; centrosome
GO:5657; replication fork
GO:43005; neuron projection
Function: GO:5515; protein binding
GO:3676; nucleic acid binding
GO:46872; metal ion binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3677; DNA binding
GO:16787; hydrolase activity
GO:42803; protein homodimerization activity
GO:4518; nuclease activity
GO:3824; catalytic activity
GO:4386; helicase activity
GO:16887; ATP hydrolysis activity
GO:4527; exonuclease activity
GO:30145; manganese ion binding
GO:287; magnesium ion binding
GO:3678; DNA helicase activity
GO:43138; 3'-5' DNA helicase activity
GO:8408; 3'-5' exonuclease activity
GO:403; Y-form DNA binding
GO:44877; protein-containing complex binding
GO:405; bubble DNA binding
GO:9378; four-way junction helicase activity
GO:61821; telomeric D-loop binding
GO:51880; G-quadruplex DNA binding
GO:400; four-way junction DNA binding
GO:61749; forked DNA-dependent helicase activity
GO:61849; telomeric G-quadruplex DNA binding
GO:1905773; 8-hydroxy-2'-deoxyguanosine DNA binding
GO:3682; chromatin binding
GO:32405; MutLalpha complex binding
GO:70337; 3'-flap-structured DNA binding
Hide GO terms

Homologs of WRN in Model Organisms

Caenorhabditis elegans
wrn-1
Danio rerio
wrn
Mus musculus
Wrn
Rattus norvegicus
Wrn
Saccharomyces cerevisiae
SGS1

In other databases

GenAge model organism genes
  • A homolog of this gene for Saccharomyces cerevisiae is present as SGS1
GenAge human genes
  • This gene is present as WRN
LongevityMap
  • This gene is present as WRN

External links

OMIM
604611
Ensembl
ENSG00000165392
Entrez Gene
7486
UniGene
632050
1000 Genomes
1000 Genomes
HPRD
GenAtlas
WRN
GeneCards
WRN