Cell Senescence Entries for WSB1
- Cell Types
- Lung fibroblast
- Cell Lines
- IMR-90
- Cancer Cell?
- No
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Inhibits
- Primary Reference
- Kim et al. (2017) WSB1 overcomes oncogene-induced senescence by targeting ATM for degradation. Cell Res 27(2)274-293 (PubMed)
WSB1 Gene Information
- HGNC symbol
- WSB1
- Aliases
- DKFZp564A122; DKFZp564B0482; SWIP1
- Common name
- WD repeat and SOCS box containing 1
- Entrez Id
- 26118
- Description
- This gene encodes a member of the WD-protein subfamily. This protein shares a high sequence identity to mouse and chick proteins. It contains several WD-repeats spanning most of the protein and an SOCS box in the C-terminus. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
WSB1 Ontologies
- Gene Ontology
-
Process: GO:16567; protein ubiquitination
GO:35556; intracellular signal transduction
GO:44314; protein K27-linked ubiquitination
GO:140454; protein aggregate center assembly
GO:8150; biological_process
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
Hide GO termsFunction: GO:5515; protein binding
GO:61630; ubiquitin protein ligase activity
Homologs of WSB1 in Model Organisms
External links
- OMIM
- 610091
- Ensembl
- ENSG00000109046
- Entrez Gene
- 26118
- UniGene
- 655024
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- WSB1
- GeneCards
- WSB1