Cell Senescence Entries for WT1

Cell Types
Lung cancer
Cell Lines
NCI-A549, NCI-H1299, NCI-H1437, NCI-H1568, NCI-H1650, NCI-H1975, NCI-H2009, NCI-H2126, NCI-H23, NCI-H358, NCI-H441, NCI-H460, NCI-H522, NCI-H727
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Vicent et al. (2010) Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models. J Clin Invest 120(11)3940-52 (PubMed)

WT1 Gene Information

HGNC symbol
WT1 
Aliases
AWT1; GUD; NPHS4; WAGR; WIT-2 
Common name
WT1 transcription factor 
Entrez Id
7490
Description
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015].

WT1 Ontologies

Gene Ontology
Process: GO:8380; RNA splicing
GO:43066; negative regulation of apoptotic process
GO:6355; regulation of transcription, DNA-templated
GO:45892; negative regulation of transcription, DNA-templated
GO:45893; positive regulation of transcription, DNA-templated
GO:1822; kidney development
GO:6357; regulation of transcription by RNA polymerase II
GO:7507; heart development
GO:8285; negative regulation of cell population proliferation
GO:30308; negative regulation of cell growth
GO:8584; male gonad development
GO:122; negative regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
GO:10628; positive regulation of gene expression
GO:30855; epithelial cell differentiation
GO:71320; cellular response to cAMP
GO:30539; male genitalia development
GO:72112; glomerular visceral epithelial cell differentiation
GO:7530; sex determination
GO:32835; glomerulus development
GO:60539; diaphragm development
GO:32836; glomerular basement membrane development
GO:1570; vasculogenesis
GO:1657; ureteric bud development
GO:30325; adrenal gland development
GO:1658; branching involved in ureteric bud morphogenesis
GO:1902895; positive regulation of pri-miRNA transcription by RNA polymerase II
GO:43010; camera-type eye development
GO:1905643; positive regulation of DNA methylation
GO:3156; regulation of animal organ formation
GO:7281; germ cell development
GO:7356; thorax and anterior abdomen determination
GO:8406; gonad development
GO:9888; tissue development
GO:35802; adrenal cortex formation
GO:60231; mesenchymal to epithelial transition
GO:60421; positive regulation of heart growth
GO:60923; cardiac muscle cell fate commitment
GO:61032; visceral serous pericardium development
GO:71371; cellular response to gonadotropin stimulus
GO:72075; metanephric mesenchyme development
GO:72166; posterior mesonephric tubule development
GO:72207; metanephric epithelium development
GO:72284; metanephric S-shaped body morphogenesis
GO:72302; negative regulation of metanephric glomerular mesangial cell proliferation
GO:2000020; positive regulation of male gonad development
GO:2000195; negative regulation of female gonad development
GO:2001076; positive regulation of metanephric ureteric bud development
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5730; nucleolus
Function: GO:3723; RNA binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:8270; zinc ion binding
GO:3700; DNA-binding transcription factor activity
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:981; DNA-binding transcription factor activity, RNA polymerase II-specific
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:976; transcription cis-regulatory region binding
GO:10385; double-stranded methylated DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:44729; hemi-methylated DNA-binding
GO:70742; C2H2 zinc finger domain binding
Hide GO terms

Homologs of WT1 in Model Organisms

Danio rerio
wt1a
Mus musculus
Wt1
Rattus norvegicus
Wt1
Schizosaccharomyces pombe
SPAC25B8.19c

External links

OMIM
607102
Ensembl
ENSG00000184937
Entrez Gene
7490
UniGene
591980
1000 Genomes
1000 Genomes
HPRD
GenAtlas
WT1
GeneCards
WT1