Cell Senescence Entries for XIAP

Cell Types
Glioblastoma
Cell Lines
U-87MG
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Lopez et al. (2012) Sensitization of glioma cells by X-linked inhibitor of apoptosis protein knockdown. Oncology 83(2)75-82 (PubMed)

XIAP Gene Information

HGNC symbol
XIAP 
Aliases
API3; BIRC4; hILP; ILP-1 
Common name
X-linked inhibitor of apoptosis 
Entrez Id
331
Description
This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011].

XIAP Ontologies

Gene Ontology
Process: GO:32268; regulation of cellular protein metabolic process
GO:42981; regulation of apoptotic process
GO:52548; regulation of endopeptidase activity
GO:43066; negative regulation of apoptotic process
GO:6915; apoptotic process
GO:16567; protein ubiquitination
GO:6974; cellular response to DNA damage stimulus
GO:16055; Wnt signaling pathway
GO:45088; regulation of innate immune response
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:10466; negative regulation of peptidase activity
GO:42127; regulation of cell population proliferation
GO:31398; positive regulation of protein ubiquitination
GO:51726; regulation of cell cycle
GO:43154; negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:50727; regulation of inflammatory response
GO:46330; positive regulation of JNK cascade
GO:10804; negative regulation of tumor necrosis factor-mediated signaling pathway
GO:30510; regulation of BMP signaling pathway
GO:97340; inhibition of cysteine-type endopeptidase activity
GO:51402; neuron apoptotic process
GO:55070; copper ion homeostasis
GO:60785; regulation of apoptosis involved in tissue homeostasis
GO:70424; regulation of nucleotide-binding oligomerization domain containing signaling pathway
GO:1902530; positive regulation of protein linear polyubiquitination
GO:1990001; inhibition of cysteine-type endopeptidase activity involved in apoptotic process
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5876; spindle microtubule
Function: GO:46872; metal ion binding
GO:16740; transferase activity
GO:5515; protein binding
GO:4842; ubiquitin-protein transferase activity
GO:42802; identical protein binding
GO:30414; peptidase inhibitor activity
GO:61630; ubiquitin protein ligase activity
GO:4869; cysteine-type endopeptidase inhibitor activity
GO:43027; cysteine-type endopeptidase inhibitor activity involved in apoptotic process
GO:120283; protein serine/threonine kinase binding
Hide GO terms

Homologs of XIAP in Model Organisms

Mus musculus
Xiap
Rattus norvegicus
Xiap

External links

OMIM
300079
Ensembl
ENSG00000101966
Entrez Gene
331
UniGene
736565
1000 Genomes
1000 Genomes
HPRD
GenAtlas
XIAP
GeneCards
XIAP