Cell Senescence Entries for XPO1

Cell Types
Fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
García-Aguirre et al. (2020) Enhanced nuclear protein export in premature aging and rescue of the progeria phenotype by modulation of CRM1 activity. Aging Cell 18(5)e13002 (PubMed)

XPO1 Gene Information

HGNC symbol
XPO1 
Aliases
CRM-1; CRM1; emb 
Common name
exportin 1 
Entrez Id
7514
Description
This cell-cycle-regulated gene encodes a protein that mediates leucine-rich nuclear export signal (NES)-dependent protein transport. The protein specifically inhibits the nuclear export of Rev and U snRNAs. It is involved in the control of several cellular processes by controlling the localization of cyclin B, MPAK, and MAPKAP kinase 2. This protein also regulates NFAT and AP-1. [provided by RefSeq, Jan 2015].

XPO1 Ontologies

Gene Ontology
Process: GO:15031; protein transport
GO:71702; organic substance transport
GO:6913; nucleocytoplasmic transport
GO:33036; macromolecule localization
GO:6611; protein export from nucleus
GO:51028; mRNA transport
GO:6886; intracellular protein transport
GO:32434; regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:54; ribosomal subunit export from nucleus
GO:55; ribosomal large subunit export from nucleus
GO:56; ribosomal small subunit export from nucleus
GO:42254; ribosome biogenesis
GO:10824; regulation of centrosome duplication
GO:34504; protein localization to nucleus
GO:42176; regulation of protein catabolic process
GO:46825; regulation of protein export from nucleus
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:16020; membrane
GO:43231; intracellular membrane-bounded organelle
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:31965; nuclear membrane
GO:5730; nucleolus
GO:15030; Cajal body
GO:776; kinetochore
GO:5635; nuclear envelope
GO:5642; annulate lamellae
GO:1990904; ribonucleoprotein complex
Function: GO:5049; nuclear export signal receptor activity
GO:5515; protein binding
GO:3723; RNA binding
GO:31267; small GTPase binding
Hide GO terms

Homologs of XPO1 in Model Organisms

Caenorhabditis elegans
xpo-1
Danio rerio
xpo1b
Drosophila melanogaster
emb
Mus musculus
Xpo1
Rattus norvegicus
Xpo1
Saccharomyces cerevisiae
CRM1
Schizosaccharomyces pombe
xpo1

In other databases

CellAge gene expression
  • This gene is present as XPO1

External links

OMIM
602559
Ensembl
ENSG00000082898
Entrez Gene
7514
UniGene
370770
1000 Genomes
1000 Genomes
HPRD
GenAtlas
XPO1
GeneCards
XPO1