Cell Senescence Entries for YAP1

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, IMR-90, WI-38
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Xie et al. (2013) YAP/TEAD-mediated transcription controls cellular senescence. Cancer Res 73(12)3615-24 (PubMed)

YAP1 Gene Information

HGNC symbol
YAP1 
Aliases
YAP65 
Common name
Yes1 associated transcriptional regulator 
Entrez Id
10413
Description
This gene encodes a downstream nuclear effector of the Hippo signaling pathway which is involved in development, growth, repair, and homeostasis. This gene is known to play a role in the development and progression of multiple cancers as a transcriptional regulator of this signaling pathway and may function as a potential target for cancer treatment. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2013].

YAP1 Ontologies

Gene Ontology
Process: GO:6974; cellular response to DNA damage stimulus
GO:122; negative regulation of transcription by RNA polymerase II
GO:35329; hippo signaling
GO:45944; positive regulation of transcription by RNA polymerase II
GO:10628; positive regulation of gene expression
GO:45747; positive regulation of Notch signaling pathway
GO:33148; positive regulation of intracellular estrogen receptor signaling pathway
GO:45893; positive regulation of transcription, DNA-templated
GO:1902018; negative regulation of cilium assembly
GO:8283; cell population proliferation
GO:70102; interleukin-6-mediated signaling pathway
GO:45599; negative regulation of fat cell differentiation
GO:45669; positive regulation of osteoblast differentiation
GO:1900182; positive regulation of protein localization to nucleus
GO:32570; response to progesterone
GO:60576; intestinal epithelial cell development
GO:71480; cellular response to gamma radiation
GO:10629; negative regulation of gene expression
GO:30307; positive regulation of cell growth
GO:65003; protein-containing complex assembly
GO:50767; regulation of neurogenesis
GO:72091; regulation of stem cell proliferation
GO:50679; positive regulation of epithelial cell proliferation
GO:50847; progesterone receptor signaling pathway
GO:60242; contact inhibition
GO:1904036; negative regulation of epithelial cell apoptotic process
GO:902; cell morphogenesis
GO:1570; vasculogenesis
GO:1824; blastocyst development
GO:1829; trophectodermal cell differentiation
GO:1894; tissue homeostasis
GO:3015; heart process
GO:3143; embryonic heart tube morphogenesis
GO:8284; positive regulation of cell population proliferation
GO:10468; regulation of gene expression
GO:10837; regulation of keratinocyte proliferation
GO:30216; keratinocyte differentiation
GO:30857; negative regulation of epithelial cell differentiation
GO:30903; notochord development
GO:35019; somatic stem cell population maintenance
GO:42060; wound healing
GO:42127; regulation of cell population proliferation
GO:46622; positive regulation of organ growth
GO:48339; paraxial mesoderm development
GO:48368; lateral mesoderm development
GO:60045; positive regulation of cardiac muscle cell proliferation
GO:60449; bud elongation involved in lung branching
GO:60487; lung epithelial cell differentiation
GO:60828; regulation of canonical Wnt signaling pathway
GO:61026; cardiac muscle tissue regeneration
GO:71300; cellular response to retinoic acid
GO:72307; regulation of metanephric nephron tubule epithelial cell differentiation
GO:90263; positive regulation of canonical Wnt signaling pathway
GO:1902459; positive regulation of stem cell population maintenance
GO:2000737; negative regulation of stem cell differentiation
GO:2001237; negative regulation of extrinsic apoptotic signaling pathway
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:30054; cell junction
GO:5829; cytosol
GO:140552; TEAD-YAP complex
GO:1674; female germ cell nucleus
GO:5667; transcription regulator complex
GO:16020; membrane
Function: GO:5515; protein binding
GO:3713; transcription coactivator activity
GO:976; transcription cis-regulatory region binding
GO:3714; transcription corepressor activity
GO:140297; DNA-binding transcription factor binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3682; chromatin binding
GO:8022; protein C-terminus binding
GO:70064; proline-rich region binding
Hide GO terms

Homologs of YAP1 in Model Organisms

Danio rerio
yap1
Mus musculus
Yap1
Rattus norvegicus
Yap1

External links

OMIM
606608
Ensembl
ENSG00000137693
Entrez Gene
10413
UniGene
503692
1000 Genomes
1000 Genomes
HPRD
GenAtlas
YAP1
GeneCards
YAP1