Cell Senescence Entries for YBX1

Cell Types
Epidermal keratinocytes
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Kwon et al. (2018) The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level. Nat Commun 9(1)1734 (PubMed)

YBX1 Gene Information

HGNC symbol
YBX1 
Aliases
BP-8; CSDA2; CSDB; DBPB; MDR-NF1; NSEP-1; NSEP1; YB-1; YB1 
Common name
Y-box binding protein 1 
Entrez Id
4904
Description
This gene encodes a highly conserved cold shock domain protein that has broad nucleic acid binding properties. The encoded protein functions as both a DNA and RNA binding protein and has been implicated in numerous cellular processes including regulation of transcription and translation, pre-mRNA splicing, DNA reparation and mRNA packaging. This protein is also a component of messenger ribonucleoprotein (mRNP) complexes and may have a role in microRNA processing. This protein can be secreted through non-classical pathways and functions as an extracellular mitogen. Aberrant expression of the gene is associated with cancer proliferation in numerous tissues. This gene may be a prognostic marker for poor outcome and drug resistance in certain cancers. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on multiple chromosomes. [provided by RefSeq, Sep 2015].

YBX1 Ontologies

Gene Ontology
Process: GO:6397; mRNA processing
GO:8380; RNA splicing
GO:6355; regulation of transcription, DNA-templated
GO:17148; negative regulation of translation
GO:51781; positive regulation of cell division
GO:10468; regulation of gene expression
GO:45944; positive regulation of transcription by RNA polymerase II
GO:70934; CRD-mediated mRNA stabilization
GO:1903608; protein localization to cytoplasmic stress granule
GO:8544; epidermis development
GO:1900152; negative regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000767; positive regulation of cytoplasmic translation
GO:48255; mRNA stabilization
GO:48598; embryonic morphogenesis
GO:1990428; miRNA transport
GO:122; negative regulation of transcription by RNA polymerase II
GO:1701; in utero embryonic development
GO:50658; RNA transport
GO:51031; tRNA transport
GO:51154; negative regulation of striated muscle cell differentiation
GO:98761; cellular response to interleukin-7
GO:2000773; negative regulation of cellular senescence
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:43231; intracellular membrane-bounded organelle
GO:5783; endoplasmic reticulum
GO:5829; cytosol
GO:5886; plasma membrane
GO:5576; extracellular region
GO:1990904; ribonucleoprotein complex
GO:10494; cytoplasmic stress granule
GO:1990124; messenger ribonucleoprotein complex
GO:5654; nucleoplasm
GO:70062; extracellular exosome
GO:70937; CRD-mediated mRNA stability complex
GO:71204; histone pre-mRNA 3'end processing complex
GO:5689; U12-type spliceosomal complex
Function: GO:5515; protein binding
GO:3676; nucleic acid binding
GO:3723; RNA binding
GO:3677; DNA binding
GO:1990837; sequence-specific double-stranded DNA binding
GO:51020; GTPase binding
GO:35198; miRNA binding
GO:3690; double-stranded DNA binding
GO:3682; chromatin binding
GO:3697; single-stranded DNA binding
GO:3729; mRNA binding
GO:62153; C5-methylcytidine-containing RNA binding
Hide GO terms

Homologs of YBX1 in Model Organisms

Danio rerio
ybx1
Mus musculus
Ybx1
Rattus norvegicus
LOC100912427

In other databases

LongevityMap
  • This gene is present as YBX1

External links

OMIM
154030
Ensembl
ENSG00000065978
Entrez Gene
4904
UniGene
473583
1000 Genomes
1000 Genomes
HPRD
GenAtlas
YBX1
GeneCards
YBX1