Cell Senescence Entries for YEATS4

Cell Types
Bronchial epithelial, Lung cancer
Cell Lines
H1355, H1993, H226, HBEC-KT, HBEC-KT53
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Pikor et al. (2014) YEATS4 is a novel oncogene amplified in non-small cell lung cancer that regulates the p53 pathway. Cancer Res 73(24)7301-12 (PubMed)

YEATS4 Gene Information

HGNC symbol
YEATS4 
Aliases
GAS41; NuBI-1; YAF9 
Common name
YEATS domain containing 4 
Entrez Id
8089
Description
The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014].

YEATS4 Ontologies

Gene Ontology
Process: GO:6355; regulation of transcription, DNA-templated
GO:6325; chromatin organization
GO:7010; cytoskeleton organization
GO:45893; positive regulation of transcription, DNA-templated
GO:40008; regulation of growth
GO:6357; regulation of transcription by RNA polymerase II
GO:6338; chromatin remodeling
GO:16573; histone acetylation
GO:43968; histone H2A acetylation
GO:43967; histone H4 acetylation
GO:278; mitotic cell cycle
GO:42981; regulation of apoptotic process
GO:51726; regulation of cell cycle
GO:1905168; positive regulation of double-strand break repair via homologous recombination
GO:2000779; regulation of double-strand break repair
GO:43486; histone exchange
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:31965; nuclear membrane
GO:16363; nuclear matrix
GO:35267; NuA4 histone acetyltransferase complex
GO:786; nucleosome
Function: GO:5515; protein binding
GO:5200; structural constituent of cytoskeleton
GO:42393; histone binding
GO:8022; protein C-terminus binding
GO:70577; lysine-acetylated histone binding
GO:140030; modification-dependent protein binding
Hide GO terms

Homologs of YEATS4 in Model Organisms

Caenorhabditis elegans
gfl-1
Danio rerio
yeats4
Drosophila melanogaster
Gas41
Mus musculus
Yeats4
Rattus norvegicus
Yeats4
Saccharomyces cerevisiae
YAF9
Schizosaccharomyces pombe
yaf9

In other databases

CellAge gene expression
  • This gene is present as YEATS4

External links

OMIM
602116
Ensembl
ENSG00000127337
Entrez Gene
8089
UniGene
4029
1000 Genomes
1000 Genomes
HPRD
GenAtlas
YEATS4
GeneCards
YEATS4