Cell Senescence Entries for YWHAZ

Cell Types
Glioblastoma
Cell Lines
A172
Cancer Cell?
Yes
Method
Knockdown, Overexpression
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2015) BIS targeting induces cellular senescence through the regulation of 14-3-3 zeta/STAT3/SKP2/p27 in glioblastoma cells. Cell Death Dis 5(2)e1537 (PubMed)

YWHAZ Gene Information

HGNC symbol
YWHAZ 
Aliases
14-3-3-zeta; KCIP-1; YWHAD 
Common name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta 
Entrez Id
7534
Description
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse, rat and sheep orthologs. The encoded protein interacts with IRS1 protein, suggesting a role in regulating insulin sensitivity. Several transcript variants that differ in the 5' UTR but that encode the same protein have been identified for this gene. [provided by RefSeq, Oct 2008].

YWHAZ Ontologies

Gene Ontology
Process: GO:7165; signal transduction
GO:1900740; positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:6468; protein phosphorylation
GO:34613; cellular protein localization
GO:122; negative regulation of transcription by RNA polymerase II
GO:43066; negative regulation of apoptotic process
GO:51683; establishment of Golgi localization
GO:90168; Golgi reassembly
GO:70372; regulation of ERK1 and ERK2 cascade
GO:90128; regulation of synapse maturation
GO:16310; phosphorylation
GO:1525; angiogenesis
GO:3016; respiratory system process
GO:6605; protein targeting
GO:8039; synaptic target recognition
GO:10941; regulation of cell death
GO:30324; lung development
GO:35148; tube formation
GO:70371; ERK1 and ERK2 cascade
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5739; mitochondrion
GO:5925; focal adhesion
GO:5615; extracellular space
GO:42470; melanosome
GO:31982; vesicle
GO:5654; nucleoplasm
GO:5829; cytosol
GO:70062; extracellular exosome
GO:72562; blood microparticle
GO:98978; glutamatergic synapse
GO:98686; hippocampal mossy fiber to CA3 synapse
Function: GO:3723; RNA binding
GO:4497; monooxygenase activity
GO:42802; identical protein binding
GO:5515; protein binding
GO:140297; DNA-binding transcription factor binding
GO:45296; cadherin binding
GO:19901; protein kinase binding
GO:31625; ubiquitin protein ligase binding
GO:44325; transmembrane transporter binding
GO:16301; kinase activity
GO:19904; protein domain specific binding
Hide GO terms

Homologs of YWHAZ in Model Organisms

Mus musculus
Ywhaz
Rattus norvegicus
Ywhaz

In other databases

GenAge human genes
  • This gene is present as YWHAZ

External links

OMIM
601288
Ensembl
ENSG00000164924
Entrez Gene
7534
UniGene
492407
1000 Genomes
1000 Genomes
HPRD
GenAtlas
YWHAZ
GeneCards
YWHAZ