Cell Senescence Entries for ZFP36

Cell Types
Cervical cancer
Cell Lines
HeLa
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Sanduja et al. (2010) The mRNA decay factor tristetraprolin (TTP) induces senescence in human papillomavirus-transformed cervical cancer cells by targeting E6-AP ubiquitin ligase. Aging (Albany NY) 1(9)803-17 (PubMed)

ZFP36 Gene Information

HGNC symbol
ZFP36 
Aliases
G0S24; NUP475; RNF162A; TIS11; TTP 
Common name
ZFP36 ring finger protein 
Entrez Id
7538
Description

ZFP36 Ontologies

Gene Ontology
Process: GO:51028; mRNA transport
GO:122; negative regulation of transcription by RNA polymerase II
GO:31047; gene silencing by RNA
GO:43488; regulation of mRNA stability
GO:165; MAPK cascade
GO:288; nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:6402; mRNA catabolic process
GO:71222; cellular response to lipopolysaccharide
GO:61158; 3'-UTR-mediated mRNA destabilization
GO:60213; positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
GO:1900153; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:2000637; positive regulation of gene silencing by miRNA
GO:71356; cellular response to tumor necrosis factor
GO:38066; p38MAPK cascade
GO:97011; cellular response to granulocyte macrophage colony-stimulating factor stimulus
GO:44344; cellular response to fibroblast growth factor stimulus
GO:42594; response to starvation
GO:9611; response to wounding
GO:45600; positive regulation of fat cell differentiation
GO:71364; cellular response to epidermal growth factor stimulus
GO:32897; negative regulation of viral transcription
GO:45616; regulation of keratinocyte differentiation
GO:71385; cellular response to glucocorticoid stimulus
GO:32680; regulation of tumor necrosis factor production
GO:70935; 3'-UTR-mediated mRNA stabilization
GO:32703; negative regulation of interleukin-2 production
GO:45647; negative regulation of erythrocyte differentiation
GO:289; nuclear-transcribed mRNA poly(A) tail shortening
GO:6357; regulation of transcription by RNA polymerase II
GO:10837; regulation of keratinocyte proliferation
GO:31086; nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
GO:35278; miRNA mediated inhibition of translation
GO:35556; intracellular signal transduction
GO:45638; negative regulation of myeloid cell differentiation
GO:50728; negative regulation of inflammatory response
GO:50779; RNA destabilization
GO:61014; positive regulation of mRNA catabolic process
GO:1901835; positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA
GO:1902172; regulation of keratinocyte apoptotic process
GO:1904246; negative regulation of polynucleotide adenylyltransferase activity
GO:1904582; positive regulation of intracellular mRNA localization
Cellular component: GO:5737; cytoplasm
GO:5634; nucleus
GO:1990904; ribonucleoprotein complex
GO:932; P-body
GO:10494; cytoplasmic stress granule
GO:5829; cytosol
GO:30014; CCR4-NOT complex
GO:70578; RISC-loading complex
Function: GO:5515; protein binding
GO:3723; RNA binding
GO:3729; mRNA binding
GO:46872; metal ion binding
GO:3677; DNA binding
GO:35925; mRNA 3'-UTR AU-rich region binding
GO:19901; protein kinase binding
GO:19899; enzyme binding
GO:71889; 14-3-3 protein binding
GO:44877; protein-containing complex binding
GO:70063; RNA polymerase binding
GO:31072; heat shock protein binding
GO:19957; C-C chemokine binding
Hide GO terms

Homologs of ZFP36 in Model Organisms

Caenorhabditis elegans
ccch-1
Mus musculus
Zfp36
Rattus norvegicus
Zfp36

External links

OMIM
190700
Ensembl
ENSG00000128016
Entrez Gene
7538
UniGene
534052
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ZFP36
GeneCards
ZFP36