Cell Senescence Entries for ZFX
- Cell Types
- NSCLC
- Cell Lines
- H1299
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Li et al. (2014) ZFX knockdown inhibits growth and migration of non-small cell lung carcinoma cell line H1299. Int J Clin Exp Pathol 6(11)2460-7 (PubMed)
ZFX Gene Information
- HGNC symbol
- ZFX
- Aliases
- ZNF926
- Common name
- zinc finger protein X-linked
- Entrez Id
- 7543
- Description
- This gene on the X chromosome is structurally similar to a related gene on the Y chromosome. It encodes a member of the krueppel C2H2-type zinc-finger protein family. The full-length protein contains an acidic transcriptional activation domain (AD), a nuclear localization sequence (NLS) and a DNA binding domain (DBD) consisting of 13 C2H2-type zinc fingers. Studies in mouse embryonic and adult hematopoietic stem cells showed that this gene was required as a transcriptional regulator for self-renewal of both stem cell types, but it was dispensable for growth and differentiation of their progeny. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, but the full-length nature of some variants has not been determined. [provided by RefSeq, May 2010].
ZFX Ontologies
- Gene Ontology
-
Process: GO:6355; regulation of transcription, DNA-templated
GO:6357; regulation of transcription by RNA polymerase II
GO:45944; positive regulation of transcription by RNA polymerase II
Cellular component: GO:5634; nucleus
GO:5654; nucleoplasm
GO:5730; nucleolus
GO:785; chromatin
GO:5694; chromosome
Hide GO termsFunction: GO:46872; metal ion binding
GO:3677; DNA binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:1228; DNA-binding transcription activator activity, RNA polymerase II-specific
GO:43035; chromatin insulator sequence binding
Homologs of ZFX in Model Organisms
- Mus musculus
- Zfx
External links
- OMIM
- 314980
- Ensembl
- ENSG00000005889
- Entrez Gene
- 7543
- UniGene
- 336681
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ZFX
- GeneCards
- ZFX