Cell Senescence Entries for ZMAT3
- Cell Types
- Breast cancer, Dermal fibroblast, Embryonic kidney, Osteosarcoma
- Cell Lines
- HEK293T, MCF-7, U2OS
- Cancer Cell?
- Yes
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Kim et al. (2013) Wig1 prevents cellular senescence by regulating p21 mRNA decay through control of RISC recruitment. EMBO J 31(22)4289-303 (PubMed)
ZMAT3 Gene Information
- HGNC symbol
- ZMAT3
- Aliases
- FLJ12296; MGC10613; PAG608; WIG-1; WIG1
- Common name
- zinc finger matrin-type 3
- Entrez Id
- 64393
- Description
- This gene encodes a protein containing three zinc finger domains and a nuclear localization signal. The mRNA and the protein of this gene are upregulated by wildtype p53 and overexpression of this gene inhibits tumor cell growth, suggesting that this gene may have a role in the p53-dependent growth regulatory pathway. Alternative splicing of this gene results in two transcript variants encoding two isoforms differing in only one amino acid. [provided by RefSeq, Jul 2008].
ZMAT3 Ontologies
- Gene Ontology
-
Process: GO:15031; protein transport
GO:6915; apoptotic process
GO:6974; cellular response to DNA damage stimulus
GO:40008; regulation of growth
Cellular component: GO:5654; nucleoplasm
GO:5634; nucleus
GO:5886; plasma membrane
GO:5730; nucleolus
Hide GO termsFunction: GO:3676; nucleic acid binding
GO:8270; zinc ion binding
GO:46872; metal ion binding
GO:3723; RNA binding
GO:5515; protein binding
Homologs of ZMAT3 in Model Organisms
- Danio rerio
- BX548160.2
- Mus musculus
- Zmat3
- Rattus norvegicus
- Zmat3
In other databases
- CellAge gene expression
- This gene is present as ZMAT3
External links
- OMIM
- 606452
- Ensembl
- ENSG00000172667
- Entrez Gene
- 64393
- UniGene
- 371609
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ZMAT3
- GeneCards
- ZMAT3