Cell Senescence Entries for ZMPSTE24

Cell Types
Umbilical cord blood-derived mesenchymal stem
Cell Lines
HUCB
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Yu et al. (2014) MicroRNA-141-3p plays a role in human mesenchymal stem cell aging by directly targeting ZMPSTE24. J Cell Sci 126(Pt 23)5422-31 (PubMed)

ZMPSTE24 Gene Information

HGNC symbol
ZMPSTE24 
Aliases
FACE-1; HGPS; PRO1; STE24; Ste24p 
Common name
zinc metallopeptidase STE24 
Entrez Id
10269
Description
This gene encodes a member of the peptidase M48A family. The encoded protein is a zinc metalloproteinase involved in the two step post-translational proteolytic cleavage of carboxy terminal residues of farnesylated prelamin A to form mature lamin A. Mutations in this gene have been associated with mandibuloacral dysplasia and restrictive dermopathy. [provided by RefSeq, Jul 2008].

ZMPSTE24 Ontologies

Gene Ontology
Process: GO:6508; proteolysis
GO:71586; CAAX-box protein processing
GO:50688; regulation of defense response to virus
GO:1889; liver development
GO:1942; hair follicle development
GO:3007; heart morphogenesis
GO:3229; ventricular cardiac muscle tissue development
GO:3231; cardiac ventricle development
GO:3417; growth plate cartilage development
GO:6281; DNA repair
GO:6325; chromatin organization
GO:6355; regulation of transcription, DNA-templated
GO:6925; inflammatory cell apoptotic process
GO:6974; cellular response to DNA damage stimulus
GO:6997; nucleus organization
GO:6998; nuclear envelope organization
GO:7346; regulation of mitotic cell cycle
GO:7628; adult walking behavior
GO:8016; regulation of heart contraction
GO:8340; determination of adult lifespan
GO:8360; regulation of cell shape
GO:8544; epidermis development
GO:10506; regulation of autophagy
GO:10628; positive regulation of gene expression
GO:10629; negative regulation of gene expression
GO:10906; regulation of glucose metabolic process
GO:16485; protein processing
GO:19216; regulation of lipid metabolic process
GO:30282; bone mineralization
GO:30327; prenylated protein catabolic process
GO:30500; regulation of bone mineralization
GO:32006; regulation of TOR signaling
GO:32350; regulation of hormone metabolic process
GO:35264; multicellular organism growth
GO:40014; regulation of multicellular organism growth
GO:43007; maintenance of rDNA
GO:43516; regulation of DNA damage response, signal transduction by p53 class mediator
GO:43969; histone H2B acetylation
GO:43979; histone H2B-K5 acetylation
GO:44029; hypomethylation of CpG island
GO:44030; regulation of DNA methylation
GO:44255; cellular lipid metabolic process
GO:48145; regulation of fibroblast proliferation
GO:48538; thymus development
GO:50905; neuromuscular process
GO:51276; chromosome organization
GO:55013; cardiac muscle cell development
GO:60307; regulation of ventricular cardiac muscle cell membrane repolarization
GO:60993; kidney morphogenesis
GO:61337; cardiac conduction
GO:61762; CAMKK-AMPK signaling cascade
GO:70302; regulation of stress-activated protein kinase signaling cascade
GO:71480; cellular response to gamma radiation
GO:72423; response to DNA damage checkpoint signaling
GO:90239; regulation of histone H4 acetylation
GO:1903025; regulation of RNA polymerase II regulatory region sequence-specific DNA binding
GO:1903463; regulation of mitotic cell cycle DNA replication
GO:1903522; regulation of blood circulation
GO:1903799; negative regulation of production of miRNAs involved in gene silencing by miRNA
GO:1990036; calcium ion import into sarcoplasmic reticulum
GO:1990164; histone H2A phosphorylation
GO:2000618; regulation of histone H4-K16 acetylation
GO:2000730; regulation of termination of RNA polymerase I transcription
GO:2000772; regulation of cellular senescence
Cellular component: GO:16020; membrane
GO:16021; integral component of membrane
GO:5783; endoplasmic reticulum
GO:5789; endoplasmic reticulum membrane
GO:5634; nucleus
GO:5637; nuclear inner membrane
GO:70062; extracellular exosome
GO:30176; integral component of endoplasmic reticulum membrane
GO:32991; protein-containing complex
GO:5635; nuclear envelope
Function: GO:46872; metal ion binding
GO:8233; peptidase activity
GO:16787; hydrolase activity
GO:8237; metallopeptidase activity
GO:4222; metalloendopeptidase activity
GO:5515; protein binding
GO:3690; double-stranded DNA binding
GO:4175; endopeptidase activity
GO:8235; metalloexopeptidase activity
Hide GO terms

Homologs of ZMPSTE24 in Model Organisms

Caenorhabditis elegans
fce-1
Danio rerio
zmpste24
Drosophila melanogaster
ste24a
Mus musculus
Zmpste24
Rattus norvegicus
Zmpste24
Saccharomyces cerevisiae
STE24
Schizosaccharomyces pombe
SPAC3H1.05

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Zmpste24
GenAge human genes

External links

OMIM
606480
Ensembl
ENSG00000084073
Entrez Gene
10269
UniGene
721062
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ZMPSTE24
GeneCards
ZMPSTE24