Cell Senescence Entries for ZNF148

Cell Types
Lung cancer
Cell Lines
NCI-H460
Cancer Cell?
Yes
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Feng et al. (2009) The transcription factor ZBP-89 suppresses p16 expression through a histone modification mechanism to affect cell senescence. FEBS J 276(15)4197-206 (PubMed)

ZNF148 Gene Information

HGNC symbol
ZNF148 
Aliases
BERF-1; BFCOL1; HT-BETA; pHZ-52; ZBP-89; ZFP148 
Common name
zinc finger protein 148 
Entrez Id
7707
Description
The protein encoded by this gene is a member of the Kruppel family of zinc finger DNA binding proteins. The encoded protein activates transcription of the T-cell receptor and intestinal alkaline phosphatase genes but represses transcription of the ornithine decarboxylase, vimentin, gastrin, stomelysin, and enolase genes. Increased expression of this gene results in decreased patient survival rates from colorectal cancer, while mutations in this gene have been associated with global developmental delay, hypoplastic corpus callosum, and dysmorphic facies. [provided by RefSeq, Feb 2017].

ZNF148 Ontologies

Gene Ontology
Process: GO:45892; negative regulation of transcription, DNA-templated
GO:10629; negative regulation of gene expression
GO:6357; regulation of transcription by RNA polymerase II
GO:122; negative regulation of transcription by RNA polymerase II
GO:21762; substantia nigra development
GO:6968; cellular defense response
GO:7276; gamete generation
GO:45944; positive regulation of transcription by RNA polymerase II
GO:65003; protein-containing complex assembly
Cellular component: GO:5634; nucleus
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
Function: GO:46872; metal ion binding
GO:3677; DNA binding
GO:43565; sequence-specific DNA binding
GO:5515; protein binding
GO:978; RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:3700; DNA-binding transcription factor activity
GO:1227; DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:976; transcription cis-regulatory region binding
GO:3690; double-stranded DNA binding
Hide GO terms

Homologs of ZNF148 in Model Organisms

Danio rerio
znf148
Mus musculus
Znf148
Rattus norvegicus
Znf148

External links

OMIM
601897
Ensembl
ENSG00000163848
Entrez Gene
7707
UniGene
717939
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ZNF148
GeneCards
ZNF148