Cell Senescence Entries for ACLY

Cell Types
Dermal fibroblast
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Lee et al. (2015) ATP-citrate lyase regulates cellular senescence via an AMPK- and p53-dependent pathway. FEBS J 282(2)361-71 (PubMed)

ACLY Gene Information

HGNC symbol
ACLY 
Aliases
ACL; ATPCL; CLATP 
Common name
ATP citrate lyase 
Entrez Id
47
Description
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Multiple transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Dec 2014].

ACLY Ontologies

Gene Ontology
Process: GO:6629; lipid metabolic process
GO:6085; acetyl-CoA biosynthetic process
GO:6101; citrate metabolic process
GO:8610; lipid biosynthetic process
GO:6633; fatty acid biosynthetic process
GO:6695; cholesterol biosynthetic process
GO:15936; coenzyme A metabolic process
GO:6107; oxaloacetate metabolic process
Cellular component: GO:5737; cytoplasm
GO:16020; membrane
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5576; extracellular region
GO:70062; extracellular exosome
GO:1904813; ficolin-1-rich granule lumen
GO:35578; azurophil granule lumen
Function: GO:46872; metal ion binding
GO:166; nucleotide binding
GO:5524; ATP binding
GO:16740; transferase activity
GO:3824; catalytic activity
GO:16829; lyase activity
GO:3878; ATP citrate synthase activity
GO:46912; acyltransferase, acyl groups converted into alkyl on transfer
GO:5515; protein binding
Hide GO terms

Homologs of ACLY in Model Organisms

Caenorhabditis elegans
acly-2
Danio rerio
aclya
Drosophila melanogaster
ATPCL
Mus musculus
Acly
Rattus norvegicus
Acly
Schizosaccharomyces pombe
SPBC1703.07

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as ATPCL
GenDR gene expression
  • A homolog of this gene for Mus musculus is present as Acly

External links

OMIM
108728
Ensembl
ENSG00000131473
Entrez Gene
47
UniGene
387567
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ACLY
GeneCards
ACLY