Cell Senescence Entries for AGT

Cell Types
Vascular smooth muscle
Cell Lines
Primary cell
Cancer Cell?
No
Method
Knockout, Overexpression
Type of senescence
Stress-induced
Senescence Effect
Induces
Primary Reference
Kunieda et al. (2006) Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 114(9)953-60 (PubMed)

AGT Gene Information

HGNC symbol
AGT 
Aliases
SERPINA8 
Common name
angiotensinogen 
Entrez Id
183
Description
The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I, is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure, body fluid and electrolyte homeostasis, and in the pathogenesis of essential hypertension and preeclampsia. Mutations in this gene are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in this gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. [provided by RefSeq, Nov 2019].

AGT Ontologies

Gene Ontology
Process: GO:10951; negative regulation of endopeptidase activity
GO:42310; vasoconstriction
GO:3081; regulation of systemic arterial blood pressure by renin-angiotensin
GO:45893; positive regulation of transcription, DNA-templated
GO:42981; regulation of apoptotic process
GO:61098; positive regulation of protein tyrosine kinase activity
GO:14068; positive regulation of phosphatidylinositol 3-kinase signaling
GO:50731; positive regulation of peptidyl-tyrosine phosphorylation
GO:7267; cell-cell signaling
GO:50729; positive regulation of inflammatory response
GO:10595; positive regulation of endothelial cell migration
GO:51092; positive regulation of NF-kappaB transcription factor activity
GO:1819; positive regulation of cytokine production
GO:10744; positive regulation of macrophage derived foam cell differentiation
GO:32270; positive regulation of cellular protein metabolic process
GO:1822; kidney development
GO:8217; regulation of blood pressure
GO:10613; positive regulation of cardiac muscle hypertrophy
GO:7186; G protein-coupled receptor signaling pathway
GO:1558; regulation of cell growth
GO:1974; blood vessel remodeling
GO:2016; regulation of blood volume by renin-angiotensin
GO:2018; renin-angiotensin regulation of aldosterone production
GO:2019; regulation of renal output by angiotensin
GO:2027; regulation of heart rate
GO:2034; maintenance of blood vessel diameter homeostasis by renin-angiotensin
GO:3014; renal system process
GO:3051; angiotensin-mediated drinking behavior
GO:3331; positive regulation of extracellular matrix constituent secretion
GO:6606; protein import into nucleus
GO:6883; cellular sodium ion homeostasis
GO:7166; cell surface receptor signaling pathway
GO:7199; G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger
GO:7200; phospholipase C-activating G protein-coupled receptor signaling pathway
GO:7202; activation of phospholipase C activity
GO:7204; positive regulation of cytosolic calcium ion concentration
GO:7263; nitric oxide mediated signal transduction
GO:7565; female pregnancy
GO:7568; aging
GO:8284; positive regulation of cell population proliferation
GO:8306; associative learning
GO:10536; positive regulation of activation of Janus kinase activity
GO:10666; positive regulation of cardiac muscle cell apoptotic process
GO:10873; positive regulation of cholesterol esterification
GO:10976; positive regulation of neuron projection development
GO:14061; regulation of norepinephrine secretion
GO:14824; artery smooth muscle contraction
GO:14873; response to muscle activity involved in regulation of muscle adaptation
GO:16525; negative regulation of angiogenesis
GO:19229; regulation of vasoconstriction
GO:30308; negative regulation of cell growth
GO:32355; response to estradiol
GO:32930; positive regulation of superoxide anion generation
GO:33864; positive regulation of NAD(P)H oxidase activity
GO:34104; negative regulation of tissue remodeling
GO:34374; low-density lipoprotein particle remodeling
GO:35106; operant conditioning
GO:35813; regulation of renal sodium excretion
GO:35815; positive regulation of renal sodium excretion
GO:42127; regulation of cell population proliferation
GO:42311; vasodilation
GO:43085; positive regulation of catalytic activity
GO:43407; negative regulation of MAP kinase activity
GO:45429; positive regulation of nitric oxide biosynthetic process
GO:45742; positive regulation of epidermal growth factor receptor signaling pathway
GO:45777; positive regulation of blood pressure
GO:46628; positive regulation of insulin receptor signaling pathway
GO:48144; fibroblast proliferation
GO:48146; positive regulation of fibroblast proliferation
GO:48169; regulation of long-term neuronal synaptic plasticity
GO:48659; smooth muscle cell proliferation
GO:51387; negative regulation of neurotrophin TRK receptor signaling pathway
GO:51403; stress-activated MAPK cascade
GO:51924; regulation of calcium ion transport
GO:51969; regulation of transmission of nerve impulse
GO:61049; cell growth involved in cardiac muscle cell development
GO:70371; ERK1 and ERK2 cascade
GO:70471; uterine smooth muscle contraction
GO:71260; cellular response to mechanical stimulus
GO:90190; positive regulation of branching involved in ureteric bud morphogenesis
GO:1901201; regulation of extracellular matrix assembly
GO:1903598; positive regulation of gap junction assembly
GO:1903779; regulation of cardiac conduction
GO:1904385; cellular response to angiotensin
GO:1904707; positive regulation of vascular associated smooth muscle cell proliferation
GO:1904754; positive regulation of vascular associated smooth muscle cell migration
GO:1905010; positive regulation of L-lysine import across plasma membrane
GO:1905589; positive regulation of L-arginine import across plasma membrane
GO:2000379; positive regulation of reactive oxygen species metabolic process
GO:2001238; positive regulation of extrinsic apoptotic signaling pathway
Cellular component: GO:5615; extracellular space
GO:5576; extracellular region
GO:5829; cytosol
GO:70062; extracellular exosome
GO:72562; blood microparticle
GO:62023; collagen-containing extracellular matrix
GO:5737; cytoplasm
Function: GO:4867; serine-type endopeptidase inhibitor activity
GO:5515; protein binding
GO:5179; hormone activity
GO:8083; growth factor activity
GO:31702; type 1 angiotensin receptor binding
GO:31703; type 2 angiotensin receptor binding
Hide GO terms

Homologs of AGT in Model Organisms

Danio rerio
agt
Mus musculus
Agt
Rattus norvegicus
Agt

In other databases

LongevityMap
  • This gene is present as AGT

External links

OMIM
106150
Ensembl
ENSG00000135744
Entrez Gene
183
UniGene
19383
1000 Genomes
1000 Genomes
HPRD
GenAtlas
AGT
GeneCards
AGT