Cell Senescence Entries for ALDH2

Cell Types
Umbilical vein endothelial
Cell Lines
HUVEC
Cancer Cell?
No
Method
Knockdown
Type of senescence
Stress-induced
Senescence Effect
Inhibits
Primary Reference
Nannelli et al. (2019) ALDH2 Activity Reduces Mitochondrial Oxygen Reserve Capacity in Endothelial Cells and Induces Senescence Properties. Oxid Med Cell Longev 2018(2)9765027 (PubMed)

ALDH2 Gene Information

HGNC symbol
ALDH2 
Aliases
 
Common name
aldehyde dehydrogenase 2 family member 
Entrez Id
217
Description
This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of aldehyde dehydrogenase, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of East Asians have the cytosolic isozyme but not the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among East Asians than among Caucasians could be related to the absence of a catalytically active form of the mitochondrial isozyme. The increased exposure to acetaldehyde in individuals with the catalytically inactive form may also confer greater susceptibility to many types of cancer. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Nov 2016].

ALDH2 Ontologies

Gene Ontology
Process: GO:22900; electron transport chain
GO:5975; carbohydrate metabolic process
GO:6066; alcohol metabolic process
GO:6068; ethanol catabolic process
GO:46185; aldehyde catabolic process
GO:1903179; regulation of dopamine biosynthetic process
GO:1905627; regulation of serotonin biosynthetic process
Cellular component: GO:5739; mitochondrion
GO:5759; mitochondrial matrix
GO:70062; extracellular exosome
Function: GO:16491; oxidoreductase activity
GO:16620; oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:52689; carboxylic ester hydrolase activity
GO:4029; aldehyde dehydrogenase (NAD+) activity
GO:43878; glyceraldehyde-3-phosphate dehydrogenase (NAD+) (non-phosphorylating) activity
GO:9055; electron transfer activity
GO:51287; NAD binding
GO:4030; aldehyde dehydrogenase [NAD(P)+] activity
GO:8957; phenylacetaldehyde dehydrogenase activity
GO:18547; nitroglycerin reductase activity
Show all GO terms

Homologs of ALDH2 in Model Organisms

Danio rerio
aldh2a
Mus musculus
Aldh2
Rattus norvegicus
Aldh2

In other databases

LongevityMap
  • This gene is present as ALDH2

External links

OMIM
100650
Ensembl
ENSG00000111275
Entrez Gene
217
UniGene
604551
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ALDH2
GeneCards
ALDH2