Cell Senescence Entries for ALKBH3

Cell Types
Lung cancer
Cell Lines
A549
Cancer Cell?
Yes
Method
Knockdown
Type of senescence
Unclear
Senescence Effect
Inhibits
Primary Reference
Tasaki et al. (2011) ALKBH3, a human AlkB homologue, contributes to cell survival in human non-small-cell lung cancer. Br J Cancer 104(4)700-6 (PubMed)

ALKBH3 Gene Information

HGNC symbol
ALKBH3 
Aliases
DEPC-1 
Common name
alkB homolog 3, alpha-ketoglutarate dependent dioxygenase 
Entrez Id
221120
Description
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008].

ALKBH3 Ontologies

Gene Ontology
Process: GO:6281; DNA repair
GO:6307; DNA dealkylation involved in DNA repair
GO:35552; oxidative single-stranded DNA demethylation
GO:6974; cellular response to DNA damage stimulus
GO:8283; cell population proliferation
GO:35553; oxidative single-stranded RNA demethylation
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5739; mitochondrion
Function: GO:16491; oxidoreductase activity
GO:51213; dioxygenase activity
GO:46872; metal ion binding
GO:5515; protein binding
GO:31418; L-ascorbic acid binding
GO:8198; ferrous iron binding
GO:43734; DNA-N1-methyladenine dioxygenase activity
Show all GO terms

Homologs of ALKBH3 in Model Organisms

Danio rerio
alkbh3
Mus musculus
Alkbh3
Rattus norvegicus
Alkbh3

External links

OMIM
610603
Ensembl
ENSG00000166199
Entrez Gene
221120
UniGene
720708
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ALKBH3
GeneCards
ALKBH3