Cell Senescence Entries for ALOX15B

Cell Types
Prostate epithelial
Cell Lines
Primary cell
Cancer Cell?
No
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Tang et al. (2007) 15-lipoxygenase 2 (15-LOX2) is a functional tumor suppressor that regulates human prostate epithelial cell differentiation, senescence, and growth (size). Prostaglandins Other Lipid Mediat 82(1-4)135-46 (PubMed)

ALOX15B Gene Information

HGNC symbol
ALOX15B 
Aliases
15-LOX-2 
Common name
arachidonate 15-lipoxygenase type B 
Entrez Id
247
Description
This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008].

ALOX15B Ontologies

Gene Ontology
Process: GO:1676; long-chain fatty acid metabolic process
GO:6690; icosanoid metabolic process
GO:6915; apoptotic process
GO:6629; lipid metabolic process
GO:6644; phospholipid metabolic process
GO:45786; negative regulation of cell cycle
GO:8285; negative regulation of cell population proliferation
GO:32722; positive regulation of chemokine production
GO:30336; negative regulation of cell migration
GO:10744; positive regulation of macrophage derived foam cell differentiation
GO:19369; arachidonic acid metabolic process
And 13 more GO terms
Cellular component: GO:5737; cytoplasm
GO:5829; cytosol
GO:5886; plasma membrane
GO:5634; nucleus
GO:16020; membrane
GO:5856; cytoskeleton
GO:5925; focal adhesion
GO:5912; adherens junction
GO:30054; cell junction
GO:70062; extracellular exosome
GO:19898; extrinsic component of membrane
And 1 more GO terms
Function: GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:5506; iron ion binding
GO:51213; dioxygenase activity
GO:16702; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:5515; protein binding
GO:5509; calcium ion binding
GO:8289; lipid binding
GO:16165; linoleate 13S-lipoxygenase activity
GO:50473; arachidonate 15-lipoxygenase activity
GO:36403; arachidonate 8(S)-lipoxygenase activity
And 2 more GO terms
Show all GO terms

Homologs of ALOX15B in Model Organisms

Danio rerio
si:dkey-17e16.9
Mus musculus
Alox15b
Rattus norvegicus
Alox15b

External links

OMIM
603697
Ensembl
ENSG00000179593
Entrez Gene
247
UniGene
111256
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ALOX15B
GeneCards
ALOX15B