Cell Senescence Entries for ANAPC1
- Cell Types
- Dermal fibroblast
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockdown
- Type of senescence
- Unclear
- Senescence Effect
- Inhibits
- Primary Reference
- Iannetti et al. (2015) Regulation of p53 and Rb links the alternative NF-κB pathway to EZH2 expression and cell senescence. PLoS Genet 10(9)e1004642 (PubMed)
ANAPC1 Gene Information
- HGNC symbol
- ANAPC1
- Aliases
- APC1; MCPR; TSG24
- Common name
- anaphase promoting complex subunit 1
- Entrez Id
- 64682
- Description
- This gene encodes a subunit of the anaphase-promoting complex. This complex is an E3 ubiquitin ligase that regulates progression through the metaphase to anaphase portion of the cell cycle by ubiquitinating proteins which targets them for degradation. [provided by RefSeq, Dec 2011].
ANAPC1 Ontologies
- Gene Ontology
-
Process: GO:7049; cell cycle
GO:16567; protein ubiquitination
GO:51301; cell division
GO:70979; protein K11-linked ubiquitination
GO:7346; regulation of mitotic cell cycle
GO:31145; anaphase-promoting complex-dependent catabolic process
GO:7091; metaphase/anaphase transition of mitotic cell cycle
GO:51445; regulation of meiotic cell cycle
Cellular component: GO:5680; anaphase-promoting complex
GO:5654; nucleoplasm
GO:5829; cytosol
GO:5634; nucleus
Show all GO termsFunction: GO:60090; molecular adaptor activity
Homologs of ANAPC1 in Model Organisms
- Danio rerio
- anapc1
- Drosophila melanogaster
- shtd
- Mus musculus
- Anapc1
- Rattus norvegicus
- Anapc1
- Schizosaccharomyces pombe
- cut4
External links
- OMIM
- 608473
- Ensembl
- ENSG00000153107
- Entrez Gene
- 64682
- UniGene
- 436527
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ANAPC1
- GeneCards
- ANAPC1