Cell Senescence Entries for APEX1

Cell Types
Foreskin fibroblast, Skin fibroblast
Cell Lines
BJ, BJ-5ta, GM00969, GM05565
Cancer Cell?
No
Method
Knockdown
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Li et al. (2019) APE1 deficiency promotes cellular senescence and premature aging features. Nucleic Acids Res 46(11)5664-5677 (PubMed)

APEX1 Gene Information

HGNC symbol
APEX1 
Aliases
APE; APE-1; APEN; APEX; APX; HAP1; REF-1; REF1 
Common name
apurinic/apyrimidinic endodeoxyribonuclease 1 
Entrez Id
328
Description
The APEX gene encodes the major AP endonuclease in human cells. It encodes the APEX endonuclease, a DNA repair enzyme with apurinic/apyrimidinic (AP) activity. Such AP activity sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. The AP sites are the most frequent pre-mutagenic lesions that can prevent normal DNA replication. Splice variants have been found for this gene; all encode the same protein. Disruptions in the biological functions related to APEX are associated with many various malignancies and neurodegenerative diseases.[provided by RefSeq, Dec 2019].

APEX1 Ontologies

Gene Ontology
Process: GO:90502; RNA phosphodiester bond hydrolysis, endonucleolytic
GO:6281; DNA repair
GO:6974; cellular response to DNA damage stimulus
GO:90305; nucleic acid phosphodiester bond hydrolysis
GO:45892; negative regulation of transcription, DNA-templated
GO:6310; DNA recombination
GO:43488; regulation of mRNA stability
GO:80111; DNA demethylation
GO:42981; regulation of apoptotic process
GO:45944; positive regulation of transcription by RNA polymerase II
GO:6284; base-excision repair
And 15 more GO terms
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5737; cytoplasm
GO:16607; nuclear speck
GO:5783; endoplasmic reticulum
GO:5654; nucleoplasm
GO:5739; mitochondrion
GO:5840; ribosome
GO:5813; centrosome
GO:5730; nucleolus
GO:48471; perinuclear region of cytoplasm
And 2 more GO terms
Function: GO:3723; RNA binding
GO:46872; metal ion binding
GO:16491; oxidoreductase activity
GO:3677; DNA binding
GO:16787; hydrolase activity
GO:3824; catalytic activity
GO:31490; chromatin DNA binding
GO:4518; nuclease activity
GO:5515; protein binding
GO:4519; endonuclease activity
GO:4527; exonuclease activity
And 22 more GO terms
Show all GO terms

Homologs of APEX1 in Model Organisms

Caenorhabditis elegans
exo-3
Danio rerio
apex1
Mus musculus
Apex1
Rattus norvegicus
Apex1

In other databases

GenAge model organism genes
  • A homolog of this gene for Caenorhabditis elegans is present as exo-3
GenAge human genes
  • This gene is present as APEX1
LongevityMap
  • This gene is present as APEX1
CellAge gene expression
  • This gene is present as APEX1

External links

OMIM
107748
Ensembl
ENSG00000100823
Entrez Gene
328
UniGene
73722
1000 Genomes
1000 Genomes
HPRD
GenAtlas
APEX1
GeneCards
APEX1