Cell Senescence Entries for ARPC1B

Cell Types
Osteosarcoma
Cell Lines
Saos-2
Cancer Cell?
Yes
Method
Overexpression
Type of senescence
Unclear
Senescence Effect
Induces
Primary Reference
Yun et al. (2011) p41-Arc, a regulatory subunit of Arp2/3 complex, can induce premature senescence in the absence of p53 and Rb. Exp Mol Med 43(7)389-92 (PubMed)

ARPC1B Gene Information

HGNC symbol
ARPC1B 
Aliases
ARC41; p40-ARC; p41-ARC 
Common name
actin related protein 2/3 complex subunit 1B 
Entrez Id
10095
Description
This gene encodes one of seven subunits of the human Arp2/3 protein complex. This subunit is a member of the SOP2 family of proteins and is most similar to the protein encoded by gene ARPC1A. The similarity between these two proteins suggests that they both may function as p41 subunit of the human Arp2/3 complex that has been implicated in the control of actin polymerization in cells. It is possible that the p41 subunit is involved in assembling and maintaining the structure of the Arp2/3 complex. Multiple versions of the p41 subunit may adapt the functions of the complex to different cell types or developmental stages. This protein also has a role in centrosomal homeostasis by being an activator and substrate of the Aurora A kinase. [provided by RefSeq, Mar 2011].

ARPC1B Ontologies

Gene Ontology
Process: GO:30833; regulation of actin filament polymerization
GO:34314; Arp2/3 complex-mediated actin nucleation
GO:32355; response to estradiol
GO:43627; response to estrogen
Cellular component: GO:5634; nucleus
GO:5737; cytoplasm
GO:5856; cytoskeleton
GO:15629; actin cytoskeleton
GO:5885; Arp2/3 protein complex
GO:5925; focal adhesion
GO:5829; cytosol
GO:70062; extracellular exosome
GO:36284; tubulobulbar complex
Function: GO:3779; actin binding
GO:5515; protein binding
GO:5200; structural constituent of cytoskeleton
GO:51015; actin filament binding
GO:44877; protein-containing complex binding
Hide GO terms

Homologs of ARPC1B in Model Organisms

Caenorhabditis elegans
arx-3
Danio rerio
arpc1b
Drosophila melanogaster
Arpc1
Mus musculus
Arpc1b
Rattus norvegicus
Arpc1b
Saccharomyces cerevisiae
ARC40
Schizosaccharomyces pombe
arc1

External links

OMIM
604223
Ensembl
ENSG00000130429
Entrez Gene
10095
UniGene
489284
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ARPC1B
GeneCards
ARPC1B