Cell Senescence Entries for ASF1A
- Cell Types
- Lung fibroblast
- Cell Lines
- Primary cell
- Cancer Cell?
- No
- Method
- Knockout, Overexpression
- Type of senescence
- Oncogene-induced, Replicative
- Senescence Effect
- Induces
- Primary Reference
- Zhang et al. (2005) Formation of MacroH2A-containing senescence-associated heterochromatin foci and senescence driven by ASF1a and HIRA. Dev Cell 8(1)19-30 (PubMed)
ASF1A Gene Information
- HGNC symbol
- ASF1A
- Aliases
- CIA; DKFZP547E2110
- Common name
- anti-silencing function 1A histone chaperone
- Entrez Id
- 25842
- Description
- This gene encodes a member of the H3/H4 family of histone chaperone proteins and is similar to the anti-silencing function-1 gene in yeast. The protein is a key component of a histone donor complex that functions in nucleosome assembly. It interacts with histones H3 and H4, and functions together with a chromatin assembly factor during DNA replication and repair. [provided by RefSeq, Jul 2008].
ASF1A Ontologies
- Gene Ontology
-
Process: GO:6325; chromatin organization
GO:6333; chromatin assembly or disassembly
GO:6335; DNA replication-dependent nucleosome assembly
GO:6336; DNA replication-independent nucleosome assembly
GO:6281; DNA repair
GO:6334; nucleosome assembly
GO:1649; osteoblast differentiation
GO:42692; muscle cell differentiation
Cellular component: GO:5634; nucleus
GO:32991; protein-containing complex
GO:5654; nucleoplasm
GO:785; chromatin
Show all GO termsFunction: GO:5515; protein binding
GO:42393; histone binding
GO:3682; chromatin binding
Homologs of ASF1A in Model Organisms
External links
- OMIM
- 609189
- Ensembl
- ENSG00000111875
- Entrez Gene
- 25842
- UniGene
- 292316
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ASF1A
- GeneCards
- ASF1A