Cell Senescence Entries for ATG7

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, IMR-90
Cancer Cell?
No
Method
Knockdown
Type of senescence
Oncogene-induced
Senescence Effect
Inhibits
Primary Reference
Young et al. (2009) Autophagy mediates the mitotic senescence transition. Genes Dev 23(7)798-803 (PubMed)

ATG7 Gene Information

HGNC symbol
ATG7 
Aliases
APG7L; DKFZp434N0735; GSA7 
Common name
autophagy related 7 
Entrez Id
10533
Description
This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015].

ATG7 Ontologies

Gene Ontology
Process: GO:15031; protein transport
GO:6914; autophagy
GO:48511; rhythmic process
GO:43065; positive regulation of apoptotic process
GO:32446; protein modification by small protein conjugation
GO:45; autophagosome assembly
GO:422; autophagy of mitochondrion
GO:6995; cellular response to nitrogen starvation
GO:9267; cellular response to starvation
GO:45732; positive regulation of protein catabolic process
GO:44805; late nucleophagy
And 10 more GO terms
Cellular component: GO:5737; cytoplasm
GO:407; phagophore assembly site
GO:5930; axoneme
GO:5576; extracellular region
GO:5829; cytosol
GO:34774; secretory granule lumen
GO:1904813; ficolin-1-rich granule lumen
Function: GO:8641; ubiquitin-like modifier activating enzyme activity
GO:42803; protein homodimerization activity
GO:5515; protein binding
GO:19778; Atg12 activating enzyme activity
GO:19779; Atg8 activating enzyme activity
Show all GO terms

Homologs of ATG7 in Model Organisms

Caenorhabditis elegans
atg-7
Danio rerio
uncharacterized_E7F5
Drosophila melanogaster
Atg7
Mus musculus
Atg7
Rattus norvegicus
Atg7
Saccharomyces cerevisiae
ATG7
Schizosaccharomyces pombe
atg7

In other databases

GenAge model organism genes
  • A homolog of this gene for Drosophila melanogaster is present as Atg7
  • A homolog of this gene for Caenorhabditis elegans is present as atg-7
  • A homolog of this gene for Saccharomyces cerevisiae is present as ATG7
GenDR gene manipulations
  • A homolog of this gene for Saccharomyces cerevisiae is present as ATG7
  • A homolog of this gene for Caenorhabditis elegans is present as atg-7

External links

OMIM
608760
Ensembl
ENSG00000197548
Entrez Gene
10533
UniGene
38032
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATG7
GeneCards
ATG7