Cell Senescence Entries for ATM

Cell Types
Foreskin fibroblast, Lung fibroblast
Cell Lines
BJ, MRC-5, WI-38
Cancer Cell?
No
Method
Knockout
Type of senescence
Replicative
Senescence Effect
Inhibits
Primary Reference
Vaziri et al. (1997) ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase. EMBO J 16(19)6018-33 (PubMed)

ATM Gene Information

HGNC symbol
ATM 
Aliases
ATA; ATC; ATD; ATDC; TEL1; TELO1 
Common name
ATM serine/threonine kinase 
Entrez Id
472
Description
The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder. [provided by RefSeq, Aug 2010].

ATM Ontologies

Gene Ontology
Process: GO:10628; positive regulation of gene expression
GO:7049; cell cycle
GO:16310; phosphorylation
GO:77; DNA damage checkpoint signaling
GO:6974; cellular response to DNA damage stimulus
GO:6281; DNA repair
GO:723; telomere maintenance
GO:6468; protein phosphorylation
GO:43065; positive regulation of apoptotic process
GO:80135; regulation of cellular response to stress
GO:724; double-strand break repair via homologous recombination
And 72 more GO terms
Cellular component: GO:781; chromosome, telomeric region
GO:5634; nucleus
GO:5737; cytoplasm
GO:31410; cytoplasmic vesicle
GO:43231; intracellular membrane-bounded organelle
GO:5654; nucleoplasm
GO:5856; cytoskeleton
GO:5730; nucleolus
GO:5813; centrosome
GO:5819; spindle
GO:5815; microtubule organizing center
And 4 more GO terms
Function: GO:44877; protein-containing complex binding
GO:166; nucleotide binding
GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:5524; ATP binding
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:3677; DNA binding
GO:5515; protein binding
GO:4672; protein kinase activity
And 5 more GO terms
Show all GO terms

Homologs of ATM in Model Organisms

Danio rerio
atm
Drosophila melanogaster
tefu
Mus musculus
Atm
Rattus norvegicus
Atm

In other databases

GenAge model organism genes
  • A homolog of this gene for Mus musculus is present as Atm
GenAge human genes
  • This gene is present as ATM
LongevityMap
  • This gene is present as ATM

External links

OMIM
607585
Ensembl
ENSG00000149311
Entrez Gene
472
UniGene
367437
1000 Genomes
1000 Genomes
HPRD
GenAtlas
ATM
GeneCards
ATM