Cell Senescence Entries for ATR
- Cell Types
- Breast cancer
- Cell Lines
- MCF-7
- Cancer Cell?
- Yes
- Method
- Overexpression
- Type of senescence
- Oncogene-induced
- Senescence Effect
- Induces
- Primary Reference
- Toledo et al. (2008) ATR signaling can drive cells into senescence in the absence of DNA breaks. Genes Dev 22(3)297-302 (PubMed)
ATR Gene Information
- HGNC symbol
- ATR
- Aliases
- FRP1; MEC1; SCKL; SCKL1
- Common name
- ATR serine/threonine kinase
- Entrez Id
- 545
- Description
- The protein encoded by this gene is a serine/threonine kinase and DNA damage sensor, activating cell cycle checkpoint signaling upon DNA stress. The encoded protein can phosphorylate and activate several proteins involved in the inhibition of DNA replication and mitosis, and can promote DNA repair, recombination, and apoptosis. This protein is also important for fragile site stability and centrosome duplication. Defects in this gene are a cause of Seckel syndrome 1. [provided by RefSeq, Aug 2017].
ATR Ontologies
- Gene Ontology
-
Process: GO:16310; phosphorylation
GO:6468; protein phosphorylation
GO:6974; cellular response to DNA damage stimulus
GO:6950; response to stress
GO:2000112; regulation of cellular macromolecule biosynthetic process
GO:6281; DNA repair
GO:31297; replication fork processing
GO:32212; positive regulation of telomere maintenance via telomerase
GO:90399; replicative senescence
GO:77; DNA damage checkpoint signaling
GO:6260; DNA replication
And 19 more GO terms Cellular component: GO:5634; nucleus
GO:781; chromosome, telomeric region
GO:5794; Golgi apparatus
GO:5654; nucleoplasm
GO:5694; chromosome
GO:16605; PML body
GO:70310; ATR-ATRIP complex
Show all GO termsFunction: GO:4674; protein serine/threonine kinase activity
GO:4712; protein serine/threonine/tyrosine kinase activity
GO:16301; kinase activity
GO:16740; transferase activity
GO:106310; protein serine kinase activity
GO:4672; protein kinase activity
GO:166; nucleotide binding
GO:5524; ATP binding
GO:3677; DNA binding
GO:5515; protein binding
GO:32405; MutLalpha complex binding
And 2 more GO terms
Homologs of ATR in Model Organisms
- Danio rerio
- atr
- Drosophila melanogaster
- mei-41
- Mus musculus
- Atr
- Rattus norvegicus
- Atr
- Saccharomyces cerevisiae
- MEC1
- Schizosaccharomyces pombe
- rad3
In other databases
- GenAge model organism genes
- A homolog of this gene for Saccharomyces cerevisiae is present as MEC1
- GenAge human genes
- This gene is present as ATR
- LongevityMap
- This gene is present as ATR
External links
- OMIM
- 601215
- Ensembl
- ENSG00000175054
- Entrez Gene
- 545
- UniGene
- 271791
- 1000 Genomes
- 1000 Genomes
- HPRD
- GenAtlas
- ATR
- GeneCards
- ATR